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THE EFFECT OF ABATACEPT ON BLOOD BIOMARKERS IN PATIENTS WITH RHEUMATOID ARTHRITIS

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Title: THE EFFECT OF ABATACEPT ON BLOOD BIOMARKERS IN PATIENTS WITH RHEUMATOID ARTHRITIS
Authors: M. A. Borisova, G. V. Lukina, Ya. A. Sigidin, E. L. Luchikhina, D. E. Karateev, A. A. Novikov, E. N. Aleksandrova, M. V. Cherkasova, E. S. Aronova, S. L. Glukhova, E. L. Nasonov
Source: Научно-практическая ревматология, Vol 55, Iss 4, Pp 368-375 (2017)
Publisher Information: IMA PRESS LLC, 2017.
Publication Year: 2017
Collection: LCC:Diseases of the musculoskeletal system
Subject Terms: abacept, rheumatoid arthritis, biological therapy, cytokines, predictors of the effectiveness of therapy, Diseases of the musculoskeletal system, RC925-935
More Details: Objective: to estimate changes in the cytokine profile in patients receiving abatacept (ABC).Subjects and methods. The investigation enrolled 44 patients with rheumatoid arthritis (RA) who had been unsuccessfully treated with disease-modifying antirheumatic drugs and biological agents. A control group included 16 healthy donors. The majority of patients were women who were positive for rheumatoid factor (RF) (80%) and antibodies to cyclic citrullinated peptide (ACCP) (79.5%); the mean age was 49.6±13.9 years; the median disease duration was 2 [1.4; 3] years with high RA activity (mean DAS28, 5.2±0.8). The serum concentrations of interleukin (IL) 1β, IL-6, IL-17AF, tumor necrosis factor-α (TNF-α), VEGF-A, IP-10, and YKL-40 were measured by enzyme immunoassay before and 6 months after ABC therapy. Disease activity was assessed using DAS28 every 3 months. ABC was infused intravenously according to the standard regimen.Results and discussion. The patients with RA as compared with the control group had significantly elevated levels of IL-6 (2.4 [1.1; 6.4] and 0.7 [0.62; 1.0] pg/ml; p=0.0002), YKL-40 (97 [68.4; 97.9] and 64 [52.4; 107.5] pg/ml; p=0.03), IP-10 (21 [12.9; 49.8] and 14 [9.2; 15.2] pg/ml, respectively; p=0.005). ABC caused a significant decrease in RA activity after 3 months of therapy (p
Document Type: article
File Description: electronic resource
Language: Russian
ISSN: 1995-4484
1995-4492
Relation: https://rsp.mediar-press.net/rsp/article/view/2409; https://doaj.org/toc/1995-4484; https://doaj.org/toc/1995-4492
DOI: 10.14412/1995-4484-2017-368-375
Access URL: https://doaj.org/article/eea8a63e1d194d8db1654ec7fabbc6bb
Accession Number: edsdoj.8a63e1d194d8db1654ec7fabbc6bb
Database: Directory of Open Access Journals
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  Data: THE EFFECT OF ABATACEPT ON BLOOD BIOMARKERS IN PATIENTS WITH RHEUMATOID ARTHRITIS
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  Data: <searchLink fieldCode="AR" term="%22M%2E+A%2E+Borisova%22">M. A. Borisova</searchLink><br /><searchLink fieldCode="AR" term="%22G%2E+V%2E+Lukina%22">G. V. Lukina</searchLink><br /><searchLink fieldCode="AR" term="%22Ya%2E+A%2E+Sigidin%22">Ya. A. Sigidin</searchLink><br /><searchLink fieldCode="AR" term="%22E%2E+L%2E+Luchikhina%22">E. L. Luchikhina</searchLink><br /><searchLink fieldCode="AR" term="%22D%2E+E%2E+Karateev%22">D. E. Karateev</searchLink><br /><searchLink fieldCode="AR" term="%22A%2E+A%2E+Novikov%22">A. A. Novikov</searchLink><br /><searchLink fieldCode="AR" term="%22E%2E+N%2E+Aleksandrova%22">E. N. Aleksandrova</searchLink><br /><searchLink fieldCode="AR" term="%22M%2E+V%2E+Cherkasova%22">M. V. Cherkasova</searchLink><br /><searchLink fieldCode="AR" term="%22E%2E+S%2E+Aronova%22">E. S. Aronova</searchLink><br /><searchLink fieldCode="AR" term="%22S%2E+L%2E+Glukhova%22">S. L. Glukhova</searchLink><br /><searchLink fieldCode="AR" term="%22E%2E+L%2E+Nasonov%22">E. L. Nasonov</searchLink>
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  Data: Научно-практическая ревматология, Vol 55, Iss 4, Pp 368-375 (2017)
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  Data: <searchLink fieldCode="DE" term="%22abacept%22">abacept</searchLink><br /><searchLink fieldCode="DE" term="%22rheumatoid+arthritis%22">rheumatoid arthritis</searchLink><br /><searchLink fieldCode="DE" term="%22biological+therapy%22">biological therapy</searchLink><br /><searchLink fieldCode="DE" term="%22cytokines%22">cytokines</searchLink><br /><searchLink fieldCode="DE" term="%22predictors+of+the+effectiveness+of+therapy%22">predictors of the effectiveness of therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Diseases+of+the+musculoskeletal+system%22">Diseases of the musculoskeletal system</searchLink><br /><searchLink fieldCode="DE" term="%22RC925-935%22">RC925-935</searchLink>
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  Data: Objective: to estimate changes in the cytokine profile in patients receiving abatacept (ABC).Subjects and methods. The investigation enrolled 44 patients with rheumatoid arthritis (RA) who had been unsuccessfully treated with disease-modifying antirheumatic drugs and biological agents. A control group included 16 healthy donors. The majority of patients were women who were positive for rheumatoid factor (RF) (80%) and antibodies to cyclic citrullinated peptide (ACCP) (79.5%); the mean age was 49.6±13.9 years; the median disease duration was 2 [1.4; 3] years with high RA activity (mean DAS28, 5.2±0.8). The serum concentrations of interleukin (IL) 1β, IL-6, IL-17AF, tumor necrosis factor-α (TNF-α), VEGF-A, IP-10, and YKL-40 were measured by enzyme immunoassay before and 6 months after ABC therapy. Disease activity was assessed using DAS28 every 3 months. ABC was infused intravenously according to the standard regimen.Results and discussion. The patients with RA as compared with the control group had significantly elevated levels of IL-6 (2.4 [1.1; 6.4] and 0.7 [0.62; 1.0] pg/ml; p=0.0002), YKL-40 (97 [68.4; 97.9] and 64 [52.4; 107.5] pg/ml; p=0.03), IP-10 (21 [12.9; 49.8] and 14 [9.2; 15.2] pg/ml, respectively; p=0.005). ABC caused a significant decrease in RA activity after 3 months of therapy (p
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