THE EFFECT OF ABATACEPT ON BLOOD BIOMARKERS IN PATIENTS WITH RHEUMATOID ARTHRITIS
| Title: | THE EFFECT OF ABATACEPT ON BLOOD BIOMARKERS IN PATIENTS WITH RHEUMATOID ARTHRITIS |
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| Authors: | M. A. Borisova, G. V. Lukina, Ya. A. Sigidin, E. L. Luchikhina, D. E. Karateev, A. A. Novikov, E. N. Aleksandrova, M. V. Cherkasova, E. S. Aronova, S. L. Glukhova, E. L. Nasonov |
| Source: | Научно-практическая ревматология, Vol 55, Iss 4, Pp 368-375 (2017) |
| Publisher Information: | IMA PRESS LLC, 2017. |
| Publication Year: | 2017 |
| Collection: | LCC:Diseases of the musculoskeletal system |
| Subject Terms: | abacept, rheumatoid arthritis, biological therapy, cytokines, predictors of the effectiveness of therapy, Diseases of the musculoskeletal system, RC925-935 |
| More Details: | Objective: to estimate changes in the cytokine profile in patients receiving abatacept (ABC).Subjects and methods. The investigation enrolled 44 patients with rheumatoid arthritis (RA) who had been unsuccessfully treated with disease-modifying antirheumatic drugs and biological agents. A control group included 16 healthy donors. The majority of patients were women who were positive for rheumatoid factor (RF) (80%) and antibodies to cyclic citrullinated peptide (ACCP) (79.5%); the mean age was 49.6±13.9 years; the median disease duration was 2 [1.4; 3] years with high RA activity (mean DAS28, 5.2±0.8). The serum concentrations of interleukin (IL) 1β, IL-6, IL-17AF, tumor necrosis factor-α (TNF-α), VEGF-A, IP-10, and YKL-40 were measured by enzyme immunoassay before and 6 months after ABC therapy. Disease activity was assessed using DAS28 every 3 months. ABC was infused intravenously according to the standard regimen.Results and discussion. The patients with RA as compared with the control group had significantly elevated levels of IL-6 (2.4 [1.1; 6.4] and 0.7 [0.62; 1.0] pg/ml; p=0.0002), YKL-40 (97 [68.4; 97.9] and 64 [52.4; 107.5] pg/ml; p=0.03), IP-10 (21 [12.9; 49.8] and 14 [9.2; 15.2] pg/ml, respectively; p=0.005). ABC caused a significant decrease in RA activity after 3 months of therapy (p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | Russian |
| ISSN: | 1995-4484 1995-4492 |
| Relation: | https://rsp.mediar-press.net/rsp/article/view/2409; https://doaj.org/toc/1995-4484; https://doaj.org/toc/1995-4492 |
| DOI: | 10.14412/1995-4484-2017-368-375 |
| Access URL: | https://doaj.org/article/eea8a63e1d194d8db1654ec7fabbc6bb |
| Accession Number: | edsdoj.8a63e1d194d8db1654ec7fabbc6bb |
| Database: | Directory of Open Access Journals |
| ISSN: | 19954484 19954492 |
|---|---|
| DOI: | 10.14412/1995-4484-2017-368-375 |
| Published in: | Научно-практическая ревматология |
| Language: | Russian |