Bibliographic Details
| Title: |
Microbial metabolites tune amygdala neuronal hyperexcitability and anxiety-linked behaviors |
| Authors: |
Weonjin Yu, Yixin Xiao, Anusha Jayaraman, Yi-Chun Yen, Hae Ung Lee, Sven Pettersson, H Shawn Je |
| Source: |
EMBO Molecular Medicine, Vol 17, Iss 2, Pp 249-264 (2025) |
| Publisher Information: |
Springer Nature, 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Medicine (General)
LCC:Genetics |
| Subject Terms: |
Gut Microbiota, Anxiety, Indoles, Neuronal Excitability, Amygdala, Medicine (General), R5-920, Genetics, QH426-470 |
| More Details: |
Abstract Changes in gut microbiota composition have been linked to anxiety behavior in rodents. However, the underlying neural circuitry linking microbiota and their metabolites to anxiety behavior remains unknown. Using male C57BL/6J germ-free (GF) mice, not exposed to live microbes, increased anxiety-related behavior was observed correlating with a significant increase in the immediate early c-Fos gene in the basolateral amygdala (BLA). This phenomenon coincided with increased intrinsic excitability and spontaneous synaptic activity of BLA pyramidal neurons associated with reduced small conductance calcium-activated potassium (SK) channel currents. Importantly, colonizing GF mice to live microbes or the microbial-derived metabolite indoles reverted SK channel activities in BLA pyramidal neurons and reduced the anxiety behavioral phenotype. These results are consistent with a molecular mechanism by which microbes and or microbial-derived indoles, regulate functional changes in the BLA neurons. Moreover, this microbe metabolite regulation of anxiety links these results to ancient evolutionarily conserved defense mechanisms associated with anxiety-related behaviors in mammals. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1757-4684 |
| Relation: |
https://doaj.org/toc/1757-4684 |
| DOI: |
10.1038/s44321-024-00179-y |
| Access URL: |
https://doaj.org/article/8a39719823a140129d6dd1bf7c288162 |
| Accession Number: |
edsdoj.8a39719823a140129d6dd1bf7c288162 |
| Database: |
Directory of Open Access Journals |
