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MEKK4-mediated Phosphorylation of HOXA10 at Threonine 362 facilitates embryo adhesion to the endometrial epithelium

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Title: MEKK4-mediated Phosphorylation of HOXA10 at Threonine 362 facilitates embryo adhesion to the endometrial epithelium
Authors: Mei Zhang, Qun Zhang, Zhiwen Cao, Xinyu Cai, Jingyu Liu, Yue Jiang, Yingchun Zhu, Jidong Zhou, Lina Yu, Xin Zhen, Yali Hu, Guijun Yan, Haixiang Sun
Source: Cell Death Discovery, Vol 8, Iss 1, Pp 1-12 (2022)
Publisher Information: Nature Publishing Group, 2022.
Publication Year: 2022
Collection: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
LCC:Cytology
Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671
More Details: Abstract Embryo adhesion is a very important step in the embryo implantation process. Homeobox A10 (HOXA10), a key transcriptional factor of endometrial receptivity, is indispensable for embryo adhesion. However, how to control the activation status of HOXA10 remains elusive. Here, we found that Mitogen-activated protein kinase kinase kinase 4 (MEKK4) was associated with HOXA10 and directly phosphorylated HOXA10 at threonine 362. This MEKK4-mediated phosphorylation enhanced HOXA10-mediated transcriptional responses and adhesion between the embryo and endometrial epithelium. Specific deletion or kinase inactivation of MEKK4 in endometrial epithelial cells attenuates adhesion between embryo and epithelium. Therefore, the identification of MEKK4 as a novel physiological positive regulator of HOXA10 activation provides mechanistic insights to improve embryo implantation success. Moreover, when Thr362 was mutated to alanine (T362A) to mimic its dephosphorylation, the protein stability and transcriptional regulation of HOXA10 were decreased. In addition, HOXA10 -promoted embryo adhesion was weakened after the mutation of Thr362, suggesting that the phosphorylation of HOXA10 at this site may be a new indicator for evaluating endometrial receptivity and judging the ‘implantation window’.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2058-7716
Relation: https://doaj.org/toc/2058-7716
DOI: 10.1038/s41420-022-01203-1
Access URL: https://doaj.org/article/8a373bbf712842bbbdb806cf373aadd3
Accession Number: edsdoj.8a373bbf712842bbbdb806cf373aadd3
Database: Directory of Open Access Journals
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  Data: MEKK4-mediated Phosphorylation of HOXA10 at Threonine 362 facilitates embryo adhesion to the endometrial epithelium
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  Data: <searchLink fieldCode="AR" term="%22Mei+Zhang%22">Mei Zhang</searchLink><br /><searchLink fieldCode="AR" term="%22Qun+Zhang%22">Qun Zhang</searchLink><br /><searchLink fieldCode="AR" term="%22Zhiwen+Cao%22">Zhiwen Cao</searchLink><br /><searchLink fieldCode="AR" term="%22Xinyu+Cai%22">Xinyu Cai</searchLink><br /><searchLink fieldCode="AR" term="%22Jingyu+Liu%22">Jingyu Liu</searchLink><br /><searchLink fieldCode="AR" term="%22Yue+Jiang%22">Yue Jiang</searchLink><br /><searchLink fieldCode="AR" term="%22Yingchun+Zhu%22">Yingchun Zhu</searchLink><br /><searchLink fieldCode="AR" term="%22Jidong+Zhou%22">Jidong Zhou</searchLink><br /><searchLink fieldCode="AR" term="%22Lina+Yu%22">Lina Yu</searchLink><br /><searchLink fieldCode="AR" term="%22Xin+Zhen%22">Xin Zhen</searchLink><br /><searchLink fieldCode="AR" term="%22Yali+Hu%22">Yali Hu</searchLink><br /><searchLink fieldCode="AR" term="%22Guijun+Yan%22">Guijun Yan</searchLink><br /><searchLink fieldCode="AR" term="%22Haixiang+Sun%22">Haixiang Sun</searchLink>
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  Data: Abstract Embryo adhesion is a very important step in the embryo implantation process. Homeobox A10 (HOXA10), a key transcriptional factor of endometrial receptivity, is indispensable for embryo adhesion. However, how to control the activation status of HOXA10 remains elusive. Here, we found that Mitogen-activated protein kinase kinase kinase 4 (MEKK4) was associated with HOXA10 and directly phosphorylated HOXA10 at threonine 362. This MEKK4-mediated phosphorylation enhanced HOXA10-mediated transcriptional responses and adhesion between the embryo and endometrial epithelium. Specific deletion or kinase inactivation of MEKK4 in endometrial epithelial cells attenuates adhesion between embryo and epithelium. Therefore, the identification of MEKK4 as a novel physiological positive regulator of HOXA10 activation provides mechanistic insights to improve embryo implantation success. Moreover, when Thr362 was mutated to alanine (T362A) to mimic its dephosphorylation, the protein stability and transcriptional regulation of HOXA10 were decreased. In addition, HOXA10 -promoted embryo adhesion was weakened after the mutation of Thr362, suggesting that the phosphorylation of HOXA10 at this site may be a new indicator for evaluating endometrial receptivity and judging the ‘implantation window’.
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