Efficacy, Safety and the Lymphocyte Subset Changes of Low-Dose IL-2 in Patients with Autoimmune Rheumatic Diseases: A Systematic Review and Meta-Analysis
| Title: | Efficacy, Safety and the Lymphocyte Subset Changes of Low-Dose IL-2 in Patients with Autoimmune Rheumatic Diseases: A Systematic Review and Meta-Analysis |
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| Authors: | Qinyi Su, Xinmiao Wang, Yongzhi Li, Jiexiang Zhang, Cairui Bai, Xuechun Wang, Liu Yang, Jingting Zhang, Sheng-Xiao Zhang |
| Source: | Rheumatology and Therapy, Vol 11, Iss 1, Pp 79-96 (2023) |
| Publisher Information: | Adis, Springer Healthcare, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Diseases of the musculoskeletal system |
| Subject Terms: | Autoimmune rheumatic diseases, Tregs, Meta-analysis, Systematic review, Low-dose Interleukin-2 (LD-IL-2), Diseases of the musculoskeletal system, RC925-935 |
| More Details: | Abstract Introduction Current therapies for autoimmune rheumatic diseases (ARDs) have limited efficacy in certain patients, highlighting the need for the development of novel treatment approaches. This meta-analysis aims to assess the efficacy and safety of low-dose interleukin-2 (LD-IL-2) and evaluate the alterations in lymphocyte subsets in various rheumatic diseases following administration of different dosages of LD-IL-2. Methods A comprehensive search was conducted in PubMed, Web of Science, the Cochrane Library, Embase databases and CNKI to identify relevant studies. A total of 31 trials were included in this meta-analysis. The review protocols were registered on PROSPERO (CRD42022318916), and the study followed the PRISMA guidelines. Results Following LD-IL-2 treatment, patients with ARDs exhibited a significant increase in the number of Th17 cells and Tregs compared to their pre-treatment levels [standardized mean difference (SMD) = 0.50, 95% confidence interval (CI) (0.33, 0.67), P |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2198-6576 2198-6584 |
| Relation: | https://doaj.org/toc/2198-6576; https://doaj.org/toc/2198-6584 |
| DOI: | 10.1007/s40744-023-00620-7 |
| Access URL: | https://doaj.org/article/8a2656f8856a4b98a505f8a85ce540c7 |
| Accession Number: | edsdoj.8a2656f8856a4b98a505f8a85ce540c7 |
| Database: | Directory of Open Access Journals |
| ISSN: | 21986576 21986584 |
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| DOI: | 10.1007/s40744-023-00620-7 |
| Published in: | Rheumatology and Therapy |
| Language: | English |