Bibliographic Details
| Title: |
Operationalizing the centiloid scale for [18F]florbetapir PET studies on PET/MRI |
| Authors: |
William Coath, Marc Modat, M. Jorge Cardoso, Pawel J. Markiewicz, Christopher A. Lane, Thomas D. Parker, Ashvini Keshavan, Sarah M. Buchanan, Sarah E. Keuss, Matthew J. Harris, Ninon Burgos, John Dickson, Anna Barnes, David L. Thomas, Daniel Beasley, Ian B. Malone, Andrew Wong, Kjell Erlandsson, Benjamin A. Thomas, Michael Schöll, Sebastien Ourselin, Marcus Richards, Nick C. Fox, Jonathan M. Schott, David M. Cash, for the Alzheimer's Disease Neuroimaging Initiative |
| Source: |
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 2, Pp n/a-n/a (2023) |
| Publisher Information: |
Wiley, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Neurology. Diseases of the nervous system
LCC:Geriatrics |
| Subject Terms: |
Alzheimer's disease, amyloid beta, centiloid, florbetapir, positron emission tomography/magnetic resonance imaging, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6 |
| More Details: |
Abstract INTRODUCTION The Centiloid scale aims to harmonize amyloid beta (Aβ) positron emission tomography (PET) measures across different analysis methods. As Centiloids were created using PET/computerized tomography (CT) data and are influenced by scanner differences, we investigated the Centiloid transformation with data from Insight 46 acquired with PET/magnetic resonanceimaging (MRI). METHODS We transformed standardized uptake value ratios (SUVRs) from 432 florbetapir PET/MRI scans processed using whole cerebellum (WC) and white matter (WM) references, with and without partial volume correction. Gaussian‐mixture‐modelling–derived cutpoints for Aβ PET positivity were converted. RESULTS The Centiloid cutpoint was 14.2 for WC SUVRs. The relationship between WM and WC uptake differed between the calibration and testing datasets, producing implausibly low WM‐based Centiloids. Linear adjustment produced a WM‐based cutpoint of 18.1. DISCUSSION Transformation of PET/MRI florbetapir data to Centiloids is valid. However, further understanding of the effects of acquisition or biological factors on the transformation using a WM reference is needed. HIGHLIGHTS Centiloid conversion of amyloid beta positron emission tomography (PET) data aims to standardize results. Centiloid values can be influenced by differences in acquisition. We converted florbetapir PET/magnetic resonance imaging data from a large birth cohort. Whole cerebellum referenced values could be reliably transformed to Centiloids. White matter referenced values may be less generalizable between datasets. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2352-8729 |
| Relation: |
https://doaj.org/toc/2352-8729 |
| DOI: |
10.1002/dad2.12434 |
| Access URL: |
https://doaj.org/article/89fc878da77c45b0abc21824ecd8a625 |
| Accession Number: |
edsdoj.89fc878da77c45b0abc21824ecd8a625 |
| Database: |
Directory of Open Access Journals |
