Bibliographic Details
| Title: |
Stem cell therapy for non-ischemic dilated cardiomyopathy: a systematic review and meta-analysis |
| Authors: |
Shiyi Tao, Lintong Yu, Jun Li, Ji Wu, Deshuang Yang, Tiantian Xue, Lanxin Zhang, Zicong Xie, Xuanchun Huang |
| Source: |
Systematic Reviews, Vol 13, Iss 1, Pp 1-13 (2024) |
| Publisher Information: |
BMC, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Medicine |
| Subject Terms: |
Stem cell therapy, Bone marrow, Dilated cardiomyopathy, Heart failure, Meta-analysis, Systematic review, Medicine |
| More Details: |
Abstract Background Stem cell therapy is the transplantation of human cells to aid the healing of damaged or wounded tissues and cells. Only a few small-scale trials have been conducted to investigate stem cell therapy for non-ischemic dilated cardiomyopathy (DCM). We aimed to perform a systematic review and meta-analysis to assess the efficacy and safety of stem cell therapy for DCM. Methods A comprehensive search of the databases of PubMed, Embase, Web of Science Core Collection, Cochrane Library, and ProQuest was conducted from their inception to June 30, 2024, to access randomized controlled trials (RCTs) that were centered on stem cell therapy for DCM. The primary outcome was left ventricular ejection fraction (LVEF), and the secondary outcomes included left ventricular end-diastolic dimension (LVEDD), left ventricular end-diastolic volume (LVEDV), 6-min walk test (6MWT), NYHA functional classification, quality of life (QoL) such as Minnesota Living with Heart Failure Questionnaire (MLHFQ) and Kansas City Cardiomyopathy Questionnaire (KCCQ), N-terminal pro-brain natriuretic peptide (NT-proBNP), and VO2 peak. Moreover, major adverse cardiovascular events (MACEs) were also recorded. The Cochrane risk-of-bias assessment tool was used to evaluate the quality of the included RCTs, and the certainty of the evidence was assessed using the GRADE method. Sensitivity analysis was taken into consideration to determine the stability of the results. This review was registered with PROSPERO (CRD42024568912). Results Eleven RCTs involving 637 participants were included in the quantitative analysis. The results indicated that there was a significant increase in mean LVEF (MD = 4.84, 95% CI 3.25–6.42, P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2046-4053 |
| Relation: |
https://doaj.org/toc/2046-4053 |
| DOI: |
10.1186/s13643-024-02701-2 |
| Access URL: |
https://doaj.org/article/addd89f792d841108ea25e4be1db3445 |
| Accession Number: |
edsdoj.89f792d841108ea25e4be1db3445 |
| Database: |
Directory of Open Access Journals |
