Bibliographic Details
| Title: |
Comparison of efficacy of intensive versus mild pitavastatin therapy on lipid and inflammation biomarkers in hypertensive patients with dyslipidemia. |
| Authors: |
Tomohiro Yamasaki, Yoshio Iwashima, Subrina Jesmin, Yuko Ohta, Hiroshi Kusunoki, Shin-ichiro Hayashi, Takeshi Horio, Yuhei Kawano |
| Source: |
PLoS ONE, Vol 9, Iss 2, p e89057 (2014) |
| Publisher Information: |
Public Library of Science (PLoS), 2014. |
| Publication Year: |
2014 |
| Collection: |
LCC:Medicine
LCC:Science |
| Subject Terms: |
Medicine, Science |
| More Details: |
ObjectiveIntensive as compared to mild statin therapy has been proven to be superior in improving cardiovascular outcome, whereas the effects of intensive statin therapy on inflammation and lipoprotein biomarkers are not well defined.MethodsThis study assigned essential hypertensive patients with dyslipidemia to 6 months administration of mild (1 mg/day, n = 34) or intensive pitavastatin therapy (4 mg/day, n = 29), and various lipid and inflammation biomarkers were measured at baseline, and 3 and 6 months after the start of treatment.ResultsBoth pitavastatin doses were well tolerated, and there were no serious treatment-related adverse events. After 6 months, significant improvements in total cholesterol, triglycerides, low-density lipoprotein (LDL-) cholesterol, LDL/high-density lipoprotein cholesterol (LDL/HDL), apolipoproteins B, C-II, and E, apolipoprotein-B/apolipoprotein-A-I (Apo B/Apo A-I), and malondialdehyde (MDA-) LDL were observed in both groups. Compared with the mild pitavastatin group, the intensive pitavastatin therapy showed significantly greater decreases in C reactive protein (F = 3.76, pConclusionIntensive pitavastatin therapy may have a more favorable effect not only in decreasing LDL-cholesterol but also in pleiotropic benefits in terms of improvement of apolipoproteins, inflammation, or oxidation. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1932-6203 |
| Relation: |
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089057&type=printable; https://doaj.org/toc/1932-6203 |
| DOI: |
10.1371/journal.pone.0089057&type=printable |
| DOI: |
10.1371/journal.pone.0089057 |
| Access URL: |
https://doaj.org/article/89c52c4e92994839aeef3ab325dffc00 |
| Accession Number: |
edsdoj.89c52c4e92994839aeef3ab325dffc00 |
| Database: |
Directory of Open Access Journals |
