Comparison of routine del Nido cardioplegia vs two types of modified del Nido cardioplegias for myocardial protection among patients undergoing coronary artery bypass grafting (CABG) surgeries: A randomized double-blind clinical trial
| Title: | Comparison of routine del Nido cardioplegia vs two types of modified del Nido cardioplegias for myocardial protection among patients undergoing coronary artery bypass grafting (CABG) surgeries: A randomized double-blind clinical trial |
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| Authors: | Ali Babar, Butt Salman Pervaiz, Nour Mohammad Ghazi, Khosravi Mohammad Bagher, Asmarian Naeimehossadat, Shoul Ali Raza, Kumar Arun, Darr Umer, Bhatnagar Gopal |
| Source: | The Journal of ExtraCorporeal Technology, Vol 56, Iss 3, Pp 84-93 (2024) |
| Publisher Information: | EDP Sciences, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Medicine |
| Subject Terms: | myocardial protection, modified del nido cardioplegia solution, coronary artery bypass grafting (cabg) surgery, Medicine |
| More Details: | Background: The del Nido cardioplegia solution is a widely used method for myocardial protection in various settings. However, there is limited evidence of its effectiveness in adult cardiac surgery, and the baseline solution, Plasma Lyte A, is not readily available, leading to the use of alternative baseline solutions. This study aims to investigate the effectiveness of routine del Nido cardioplegia in adult cardiac surgery and the impact of different baseline solutions on myocardial protection and other perioperative outcomes. Methods: This study was a prospective, double-blind randomized parallel group clinical trial conducted at a single tertiary care hospital in Iran. A total of 187 adult patients were evaluated for eligibility, of which 120 met the inclusion criteria for elective isolated CABG surgery. The patients were randomly assigned to three groups, with each group consisting of 40 patients. The control group received a normal saline-based routine del Nido cardioplegia, Intervention Group A received Ringer lactate-based del Nido cardioplegia, and Intervention Group B received plain Ringer-based del Nido cardioplegia. The levels of Creatine Kinase-MB (CK-MB), Troponin T, Troponin I, and lactate were primarily assessed at four different times: after anesthesia induction (Baseline), 2 h, 12 h, and 24 h. Results: Preoperative demographic and clinical characteristics were the same among groups with insignificant differences (p > 0.05). There was no significant difference among groups based on CK-MB, Troponin T, Troponin I, and lactate levels (p = 0.078, 0.143, 0.311, and 0.129 respectively). However, there was a significant difference in the time effect of Troponin T and Lactate (p = 0.034, p = |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 0022-1058 2969-8960 |
| Relation: | https://ject.edpsciences.org/articles/ject/full_html/2024/03/ject240004/ject240004.html; https://doaj.org/toc/0022-1058; https://doaj.org/toc/2969-8960 |
| DOI: | 10.1051/ject/2024011 |
| Access URL: | https://doaj.org/article/d89b922eb13743859827a246e5326fe7 |
| Accession Number: | edsdoj.89b922eb13743859827a246e5326fe7 |
| Database: | Directory of Open Access Journals |
| ISSN: | 00221058 29698960 |
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| DOI: | 10.1051/ject/2024011 |
| Published in: | The Journal of ExtraCorporeal Technology |
| Language: | English |