Bibliographic Details
| Title: |
A challenging case of stage IV EGFR-mutant lung cancer with histologic transformation and multiple resistance mechanisms |
| Authors: |
Joel Rivera-Concepcion, Ying-Chun Lo, Dipesh Uprety, Alex A. Adjei, Vinicius Ernani, Konstantinos Leventakos |
| Source: |
Current Problems in Cancer: Case Reports, Vol 13, Iss , Pp 100284- (2024) |
| Publisher Information: |
Elsevier, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
NSCLC, EGFR mutation, Histologic transformation, Acquired resistance, Neuroendocrine cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
This clinical case presents a patient with NSCLC who experienced on-target resistant mutations and tumor cell transformation from adenocarcinoma to large cell neuroendocrine and small cell carcinoma. Our patient was successfully treated with a combination of targeted therapy, immunotherapy and chemotherapy based on genetic and histologic changes that occurred in a period of five years. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2666-6219 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2666621924000073; https://doaj.org/toc/2666-6219 |
| DOI: |
10.1016/j.cpccr.2024.100284 |
| Access URL: |
https://doaj.org/article/89b01e3fc5fe4031b3866f1dd44b3b45 |
| Accession Number: |
edsdoj.89b01e3fc5fe4031b3866f1dd44b3b45 |
| Database: |
Directory of Open Access Journals |
