Bibliographic Details
| Title: |
Efficacy of RCI001 as a therapeutic candidate of dry eye disease in a modified mixed dry eye model |
| Authors: |
Young-ho Jung, Young Ah Ku, Jayoon Moon, Seunghoon Kim, Jin Suk Ryu, Chang Ho Yoon, Myung Hee Chung, Yong Ho Kim, Mee Kum Kim, Dong Hyun Kim |
| Source: |
Eye and Vision, Vol 11, Iss 1, Pp 1-11 (2024) |
| Publisher Information: |
BMC, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Ophthalmology |
| Subject Terms: |
RCI001, Dry eye disease, Inflammation, Oxidative stress, Therapeutics, Ophthalmology, RE1-994 |
| More Details: |
Abstract Background To evaluate the therapeutic effects of topical RCI001 (RCI) and compare its efficacy with that of 1% prednisolone acetate (PDE) and 5% Lifitegrast in a modified mixed dry eye disease (DED) model. Methods The environmental DED model was induced in BALB/c mice in a dry chamber with scopolamine. The eyes of the mice were treated topically with phosphate buffered saline (PBS), PDE, Lifitegrast or RCI twice daily for 1 week. Ocular surface staining (OSS), tear secretion, inflammatory cytokines in the ocular surface and lacrimal gland, and immunofluorescence staining in the conjunctiva and cornea(CC) were assessed. Results The RCI group demonstrated better improvement of OSS and tear secretion than the PBS group (OSS, PBS: 13.0 ± 1.6, RCI: 9.4 ± 3.0; tear secretion, PBS: 5.0 ± 0.4 mm, RCI: 7.0 ± 0.3 mm, each P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2326-0254 |
| Relation: |
https://doaj.org/toc/2326-0254 |
| DOI: |
10.1186/s40662-024-00388-z |
| Access URL: |
https://doaj.org/article/e89ac063859248f8a49e1b44a6cccf63 |
| Accession Number: |
edsdoj.89ac063859248f8a49e1b44a6cccf63 |
| Database: |
Directory of Open Access Journals |
