Adenocarcinoma on needle prostatic biopsies: Does reactive stroma predicts biochemical recurrence in patients following radical prostatectomy?
| Title: | Adenocarcinoma on needle prostatic biopsies: Does reactive stroma predicts biochemical recurrence in patients following radical prostatectomy? |
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| Authors: | Athanase Billis, Luciana Meirelles, Leandro L.L. Freitas, Aline S. Polidoro, Hamilton A. Fernandes, Mariana M. Padilha, Luis A. Magna, Leonardo O. Reis, Ubirajara Ferreira |
| Source: | International Brazilian Journal of Urology, Vol 39, Iss 3, Pp 320-327 (2013) |
| Publisher Information: | Sociedade Brasileira de Urologia, 2013. |
| Publication Year: | 2013 |
| Collection: | LCC:Diseases of the genitourinary system. Urology |
| Subject Terms: | Fibrosis, Prognosis, Prostatic Neoplasms, Humans, Recurrence, Disease Progression, Diseases of the genitourinary system. Urology, RC870-923 |
| More Details: | Objective There is evidence that reactive stroma in different cancers may regulate tumor progression. The aim of this study is to establish any possible relation of reactive stroma grading on needle prostatic biopsies to biochemical recurrence. Materials and Methods The study group comprised 266 biopsies from consecutive patients submitted to radical prostatectomy. Reactive stroma was defined as stroma surrounding neoplastic tissue and graded as 0 (absent), 1 (slight), 2 (moderate), and 3 (intense) according to tumor stroma area relative to total tumor area. Results From the total of 266 needle prostatic biopsies, 143 (53.8%), 55 (20.7%), 54 (20.3%), and 14 (5.3%) showed grades 0, 1, 2, and 3, respectively. Increasing reactive stroma grade was significantly associated with clinical stage T2, higher preoperative PSA, higher biopsy and radical prostatectomy Gleason score, more extensive tumors in radical prostatectomy, and pathologic stage > T2. Only grade 3 was significantly associated with time and risk to biochemical recurrence. On multivariate analysis only preoperative PSA and 2 methods of biopsy tumor extent evaluation were independent predictors. Conclusion Increasing reactive stroma grade on biopsies is significantly associated with several clinicopathologic adverse findings, however, only grade 3 predicts time and risk to biochemical recurrence following radical prostatectomy on univariate but not on multivariate analysis. We have not been able to show that reactive stroma grade 3 on biopsies is an independent predictor of biochemical recurrence beyond that of preoperative PSA and other pathologic findings on biopsy. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1677-6119 1677-5538 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382013000300320&lng=en&tlng=en; https://doaj.org/toc/1677-6119 |
| DOI: | 10.1590/S1677-5538.IBJU.2013.03.04 |
| Access URL: | https://doaj.org/article/8975e67fc58d4f31afd1900661f2234d |
| Accession Number: | edsdoj.8975e67fc58d4f31afd1900661f2234d |
| Database: | Directory of Open Access Journals |
| ISSN: | 16776119 16775538 |
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| DOI: | 10.1590/S1677-5538.IBJU.2013.03.04 |
| Published in: | International Brazilian Journal of Urology |
| Language: | English |