Antiproliferative and proapoptotic effects of extract on Burkitt lymphoma cell line

Bibliographic Details
Title:	Antiproliferative and proapoptotic effects of extract on Burkitt lymphoma cell line
Authors:	Patrizia Virdis, Rossana Migheli, Grazia Galleri, Silvia Fancello, Maria Piera L Cadoni, Giorgio Pintore, Giacomo Luigi Petretto, Irene Marchesi, Francesco Paolo Fiorentino, Alessandra di Francesco, Francesca Sanges, Luigi Bagella, Maria Rosaria Muroni, Claudio Fozza, Maria Rosaria De Miglio, Luigi Podda
Source:	Tumor Biology, Vol 42 (2020)
Publisher Information:	IOS Press, 2020.
Publication Year:	2020
Collection:	LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Subject Terms:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
More Details:	Burkitt lymphoma is a very aggressive B-cell non-Hodgkin lymphoma. Although remarkable progress has been made in the therapeutic scenario for patients with Burkitt lymphoma, search and development of new effective anticancer agents to improve patient outcome and minimize toxicity has become an urgent issue. In this study, the antitumoral activity of Inula viscosa , a traditional herb obtained from plants collected on the Asinara Island, Italy, was evaluated in order to explore potential antineoplastic effects of its metabolites on Burkitt lymphoma. Raji human cell line was treated with increasing Inula viscosa extract concentration for cytotoxicity screening and subsequent establishment of cell cycle arrest and apoptosis. Moreover, gene expression profiles were performed to identify molecular mechanisms involved in the anticancer activities of this medical plant. The Inula viscosa extract exhibited powerful antiproliferative and cytotoxic activities on Raji cell line, showing a dose- and time-dependent decrease in cell viability, obtained by cell cycle arrest in the G2/M phase and an increase in cell apoptosis. The treatment with Inula viscosa caused downregulation of genes involved in cell cycle and proliferation (c-MYC, CCND1) and inhibition of cell apoptosis (BCL2, BCL2L1, BCL11A). The Inula viscosa extract causes strong anticancer effects on Burkitt lymphoma cell line. The molecular mechanisms underlying such antineoplastic activity are based on targeting and downregulation of genes involved in cell cycle and apoptosis. Our data suggest that Inula viscosa natural metabolites should be further exploited as potential antineoplastic agents against Burkitt lymphoma.
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	1423-0380 10104283
Relation:	https://doaj.org/toc/1423-0380
DOI:	10.1177/1010428319901061
Access URL:	https://doaj.org/article/88fdaf1d7f604d42bef30ad534c54c4e
Accession Number:	edsdoj.88fdaf1d7f604d42bef30ad534c54c4e
Database:	Directory of Open Access Journals

More Details
ISSN:	14230380 10104283
DOI:	10.1177/1010428319901061
Published in:	Tumor Biology
Language:	English