Marine Natural Product Inhibitors of Neutrophil-Associated Inflammation
| Title: | Marine Natural Product Inhibitors of Neutrophil-Associated Inflammation |
|---|---|
| Authors: | Chun-Yu Chen, Yung-Fong Tsai, Wen-Yi Chang, Shun-Chin Yang, Tsong-Long Hwang |
| Source: | Marine Drugs, Vol 14, Iss 8, p 141 (2016) |
| Publisher Information: | MDPI AG, 2016. |
| Publication Year: | 2016 |
| Collection: | LCC:Biology (General) |
| Subject Terms: | marine natural products, neutrophils, anti-inflammatory, reactive oxygen species, formyl peptide receptor, phospholipase, Biology (General), QH301-705.5 |
| More Details: | Neutrophils are widely recognized to play an important role in acute inflammatory responses, and recent evidence has expanded their role to modulating chronic inflammatory and autoimmune diseases. Reactive oxygen species (ROS) and microbicidal compounds released from neutrophils that are recruited to the site of inflammation contribute to the pathogenesis of multiple inflammation-associated diseases such as chronic obstructive pulmonary disease, atherosclerosis, and hepatitis. Marine organisms are a valuable source of bioactive compounds with potential for industrial and pharmaceutical application. Marine natural products that inhibit neutrophil activation could be used as drugs for the treatment of inflammatory diseases. Numerous studies investigating marine natural products have reported novel anti-inflammatory agents. Nevertheless, the detailed mechanisms underlying their actions, which could facilitate our understanding of the molecular events occurring in neutrophils, have not been reported in most of the associated research studies. Therefore, in this review, we will present marine products that inhibit neutrophil-associated inflammation. Furthermore, we will be limiting the detailed discussion to agents with well-investigated molecular targets. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1660-3397 14080141 |
| Relation: | http://www.mdpi.com/1660-3397/14/8/141; https://doaj.org/toc/1660-3397 |
| DOI: | 10.3390/md14080141 |
| Access URL: | https://doaj.org/article/88f30d8607d5494a8e14ebcac2186152 |
| Accession Number: | edsdoj.88f30d8607d5494a8e14ebcac2186152 |
| Database: | Directory of Open Access Journals |
| ISSN: | 16603397 14080141 |
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| DOI: | 10.3390/md14080141 |
| Published in: | Marine Drugs |
| Language: | English |