The RYR3 gene is involved in Wharton’s jelly derived mesenchymal stem cell treatment of Alzheimer’s disease in rats
| Title: | The RYR3 gene is involved in Wharton’s jelly derived mesenchymal stem cell treatment of Alzheimer’s disease in rats |
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| Authors: | Hirowati Ali, Tofrizal Tofrizal, Djong Hon Tjong, Amel Yanis, Sisca Dwi Yarni |
| Source: | Archives of Medical Science, Vol 19, Iss 3, Pp 820-824 (2023) |
| Publisher Information: | Termedia Publishing House, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Medicine |
| Subject Terms: | alzheimer’s disease (ad), mesenchymal stem cells (mscs), cognitive dysfunction, ryr3 gene, ca2+ homeostasis, Medicine |
| More Details: | Introduction Our study aims to observe the effect of mesenchymal stem cells (MSCs) in lowering amyloid accumulation and ryanodine receptor 3 (RYR3) gene expression, further improving cognitive dysfunction in Alzheimer’s disease (AD). Material and methods Twenty male adult Wistar rats were randomly distributed into three groups of animals (n = 5). The AlCl3 group was given 300 mg/kg body weight (BW) of AlCl3 intraperitoneally for 5 days, further the MSC injection, and their effect after 30 days was observed. Results MSCs improved amyloid accumulation and Y-maze scores, and expression of the RYR3 gene decreased compared to the control group. Conclusions MSCs improved amyloid accumulation, Y-maze scores, and RYR3 expression in the AD animal model. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1734-1922 1896-9151 |
| Relation: | https://www.archivesofmedicalscience.com/The-RYR3-gene-is-involved-in-Wharton-s-jelly-derived-mesenchymal-stem-cell-treatment,163353,0,2.html; https://doaj.org/toc/1734-1922; https://doaj.org/toc/1896-9151 |
| DOI: | 10.5114/aoms/163353 |
| Access URL: | https://doaj.org/article/88e4af6b26434521b372c4bc62f296b3 |
| Accession Number: | edsdoj.88e4af6b26434521b372c4bc62f296b3 |
| Database: | Directory of Open Access Journals |
| ISSN: | 17341922 18969151 |
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| DOI: | 10.5114/aoms/163353 |
| Published in: | Archives of Medical Science |
| Language: | English |