Bibliographic Details
| Title: |
Advanced glycation end products and their soluble receptor (sRAGE) in patients with Hashimoto’s thyroiditis on levothyroxine substitution |
| Authors: |
Sára Csiha, István Molnár, Sándor Halmi, Dávid Hutkai, Hajnalka Lőrincz, Sándor Somodi, Mónika Katkó, Mariann Harangi, György Paragh, Endre V. Nagy, Eszter Berta, Miklós Bodor |
| Source: |
Frontiers in Endocrinology, Vol 14 (2023) |
| Publisher Information: |
Frontiers Media S.A., 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Diseases of the endocrine glands. Clinical endocrinology |
| Subject Terms: |
thyroid, advanced glycation end products, sRAGE, hypothyroidism, Hashimoto’s thyroiditis, levothyroxine, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| More Details: |
BackgroundAdvanced glycation end products (AGEs) are heterogenous group of irreversible chemical moieties originated from non-enzymatic glycation and oxidation of proteins, nucleic acids, and lipids. The engagement of AGEs with their chief cellular receptor (RAGE) activates a myriad of signaling pathways contributing to the progression of chronic diseases like autoimmune thyroiditis, type 2 diabetes mellitus and its complications. Soluble RAGE (sRAGE) prevents AGE-RAGE interaction in a competitive manner.ObjectiveWe investigated the association between serum AGE, sRAGE and thyroid function in 73 Hashimoto thyroiditis patients (HT) on levothyroxine substitution, and in 83 age, BMI and gender-matched healthy controls.MethodsThe serum AGEs levels were determined by autofluorescence on a multi-mode microplate reader, and the serum sRAGE levels by ELISA method.ResultsMean AGE level was lower (10.71 vs 11.45 AU/µg protein; p=0.046), while mean sRAGE level was higher (923 vs 755 pg/mL; p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-2392 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fendo.2023.1187725/full; https://doaj.org/toc/1664-2392 |
| DOI: |
10.3389/fendo.2023.1187725 |
| Access URL: |
https://doaj.org/article/cad884cd3a234e82a3ef85cfed3638fc |
| Accession Number: |
edsdoj.884cd3a234e82a3ef85cfed3638fc |
| Database: |
Directory of Open Access Journals |
