Pentoxifylline ameliorates carbamazepine-induced hepatotoxicity via down expression of CYP3A4 and NF-kB gene expression in the rat: in vivo study
| Title: | Pentoxifylline ameliorates carbamazepine-induced hepatotoxicity via down expression of CYP3A4 and NF-kB gene expression in the rat: in vivo study |
|---|---|
| Authors: | Farah Rafie Mohammed, Yassir Mustafa Kamal Al Mulla Hummadi, Muthanna I. Al-Ezzi |
| Source: | Pharmacia, Vol 71, Iss , Pp 1-11 (2024) |
| Publisher Information: | Pensoft Publishers, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Pharmacy and materia medica |
| Subject Terms: | Pharmacy and materia medica, RS1-441 |
| More Details: | Drug-induced liver injury (DILI) is a serious complication of many drugs, including carbamazepine; this study investigates the protective effect of pentoxifylline (PTX) against DILI induced by carbamazepine in rat models by attenuating CYP3A4 and NF-κB gene expression. Forty rats were divided into five groups: the control group received no treatment, the induction group received 50 mg/kg carbamazepine orally for 28 days, and three groups received PTX (100, 200, and 300 mg/kg) once daily for one hour before carbamazepine induction for 28 days. Then, the rats were euthanized, and blood and liver tissue were collected for biochemical, gene expression, and histopathology. PTX attenuates the carbamazepine-induced increased CYP3A4 and NF-κB gene expression, with the highest dose showing the best result. PTX also reduced aspartate aminotransferase, alanine aminotransferase, and malondialdehyde, while glutathione levels increased. In conclusion, PTX is highly efficacious in preventing and restoring the liver cells’ normal morphology and cellular function caused by carbamazepine hepatotoxicity. A possible mechanism of the PTC effect is hindering oxidative stress by scavenging free radicals and enhancing the body’s natural defense antioxidant system. Additionally, it exerts an anti-inflammatory impact by modulating NF-κB gene expression. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2603-557X |
| Relation: | https://pharmacia.pensoft.net/article/136976/download/pdf/; https://pharmacia.pensoft.net/article/136976/download/xml/; https://pharmacia.pensoft.net/article/136976/; https://doaj.org/toc/2603-557X |
| DOI: | 10.3897/pharmacia.71.e136976 |
| Access URL: | https://doaj.org/article/884647b40748473abc989a8a93b02795 |
| Accession Number: | edsdoj.884647b40748473abc989a8a93b02795 |
| Database: | Directory of Open Access Journals |
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| Items | – Name: Title Label: Title Group: Ti Data: Pentoxifylline ameliorates carbamazepine-induced hepatotoxicity via down expression of CYP3A4 and NF-kB gene expression in the rat: in vivo study – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Farah+Rafie+Mohammed%22">Farah Rafie Mohammed</searchLink><br /><searchLink fieldCode="AR" term="%22Yassir+Mustafa+Kamal+Al+Mulla+Hummadi%22">Yassir Mustafa Kamal Al Mulla Hummadi</searchLink><br /><searchLink fieldCode="AR" term="%22Muthanna+I%2E+Al-Ezzi%22">Muthanna I. Al-Ezzi</searchLink> – Name: TitleSource Label: Source Group: Src Data: Pharmacia, Vol 71, Iss , Pp 1-11 (2024) – Name: Publisher Label: Publisher Information Group: PubInfo Data: Pensoft Publishers, 2024. – Name: DatePubCY Label: Publication Year Group: Date Data: 2024 – Name: Subset Label: Collection Group: HoldingsInfo Data: LCC:Pharmacy and materia medica – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Pharmacy+and+materia+medica%22">Pharmacy and materia medica</searchLink><br /><searchLink fieldCode="DE" term="%22RS1-441%22">RS1-441</searchLink> – Name: Abstract Label: Description Group: Ab Data: Drug-induced liver injury (DILI) is a serious complication of many drugs, including carbamazepine; this study investigates the protective effect of pentoxifylline (PTX) against DILI induced by carbamazepine in rat models by attenuating CYP3A4 and NF-κB gene expression. Forty rats were divided into five groups: the control group received no treatment, the induction group received 50 mg/kg carbamazepine orally for 28 days, and three groups received PTX (100, 200, and 300 mg/kg) once daily for one hour before carbamazepine induction for 28 days. Then, the rats were euthanized, and blood and liver tissue were collected for biochemical, gene expression, and histopathology. PTX attenuates the carbamazepine-induced increased CYP3A4 and NF-κB gene expression, with the highest dose showing the best result. PTX also reduced aspartate aminotransferase, alanine aminotransferase, and malondialdehyde, while glutathione levels increased. In conclusion, PTX is highly efficacious in preventing and restoring the liver cells’ normal morphology and cellular function caused by carbamazepine hepatotoxicity. A possible mechanism of the PTC effect is hindering oxidative stress by scavenging free radicals and enhancing the body’s natural defense antioxidant system. Additionally, it exerts an anti-inflammatory impact by modulating NF-κB gene expression. – Name: TypeDocument Label: Document Type Group: TypDoc Data: article – Name: Format Label: File Description Group: SrcInfo Data: electronic resource – Name: Language Label: Language Group: Lang Data: English – Name: ISSN Label: ISSN Group: ISSN Data: 2603-557X – Name: NoteTitleSource Label: Relation Group: SrcInfo Data: https://pharmacia.pensoft.net/article/136976/download/pdf/; https://pharmacia.pensoft.net/article/136976/download/xml/; https://pharmacia.pensoft.net/article/136976/; https://doaj.org/toc/2603-557X – Name: DOI Label: DOI Group: ID Data: 10.3897/pharmacia.71.e136976 – Name: URL Label: Access URL Group: URL Data: <link linkTarget="URL" linkTerm="https://doaj.org/article/884647b40748473abc989a8a93b02795" linkWindow="_blank">https://doaj.org/article/884647b40748473abc989a8a93b02795</link> – Name: AN Label: Accession Number Group: ID Data: edsdoj.884647b40748473abc989a8a93b02795 |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3897/pharmacia.71.e136976 Languages: – Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 1 Subjects: – SubjectFull: Pharmacy and materia medica Type: general – SubjectFull: RS1-441 Type: general Titles: – TitleFull: Pentoxifylline ameliorates carbamazepine-induced hepatotoxicity via down expression of CYP3A4 and NF-kB gene expression in the rat: in vivo study Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Farah Rafie Mohammed – PersonEntity: Name: NameFull: Yassir Mustafa Kamal Al Mulla Hummadi – PersonEntity: Name: NameFull: Muthanna I. Al-Ezzi IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 2603557X Numbering: – Type: volume Value: 71 – Type: issue Value: 1-11 Titles: – TitleFull: Pharmacia Type: main |
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