Non-alcoholic fatty pancreas disease: an updated review
| Title: | Non-alcoholic fatty pancreas disease: an updated review |
|---|---|
| Authors: | Chaoyu Pang, Peng Dong, Jian Yang, Zhiyao Fan, Zhiqiang Cheng, Hanxiang Zhan |
| Source: | Journal of Pancreatology, Vol 7, Iss 3, Pp 212-221 (2024) |
| Publisher Information: | Wolters Kluwer Health/LWW, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Diseases of the digestive system. Gastroenterology |
| Subject Terms: | Diseases of the digestive system. Gastroenterology, RC799-869 |
| More Details: | Ectopic accumulation of fat can cause a variety of metabolic diseases, and the emerging non-alcoholic fatty pancreas disease (NAFPD) is increasingly being recognized by clinicians as a cause for concern. NAFPD is a disease caused by abnormal accumulation of adipose tissue in the pancreas, which is related to obesity. The main feature of NAFPD is death of acinar cells, which are then replaced by adipose cells. However, the underlying molecular mechanisms have not been fully explored. Obesity, aging, and metabolic syndrome are independent risk factors for the occurrence and development of NAFPD. Studies have shown that NAFPD leads to insulin resistance and pancreatic dysfunction, increases the risk of diabetes mellitus, worsens the severity of pancreatitis, and is significantly correlated with pancreatic cancer and postoperative pancreatic fistula. There is no standard treatment for NAFPD; exercise, a balanced diet, and lifestyle can help reduce pancreatic fat; however, other treatment modalities such as drugs and bariatric surgery are still being explored. The specific pathological mechanism of NAFPD remains unclear, and its potential association with various clinical diseases requires further study. This review summarizes the etiology, diagnosis, clinical consequences, and potential therapeutic strategies of NAFPD. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2096-5664 2577-3577 00000000 |
| Relation: | http://journals.lww.com/10.1097/JP9.0000000000000157; https://doaj.org/toc/2096-5664; https://doaj.org/toc/2577-3577 |
| DOI: | 10.1097/JP9.0000000000000157 |
| Access URL: | https://doaj.org/article/87f31555623d4fbabf4a03882cccdc7e |
| Accession Number: | edsdoj.87f31555623d4fbabf4a03882cccdc7e |
| Database: | Directory of Open Access Journals |
| ISSN: | 20965664 25773577 00000000 |
|---|---|
| DOI: | 10.1097/JP9.0000000000000157 |
| Published in: | Journal of Pancreatology |
| Language: | English |