Genomic landscape of advanced basal cell carcinoma: Implications for precision treatment with targeted and immune therapies
| Title: | Genomic landscape of advanced basal cell carcinoma: Implications for precision treatment with targeted and immune therapies |
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| Authors: | Aaron M. Goodman, Shumei Kato, Philip R. Cohen, Amélie Boichard, Garrett Frampton, Vincent Miller, Philip J. Stephens, Gregory A. Daniels, Razelle Kurzrock |
| Source: | OncoImmunology, Vol 7, Iss 3 (2018) |
| Publisher Information: | Taylor & Francis Group, 2018. |
| Publication Year: | 2018 |
| Collection: | LCC:Immunologic diseases. Allergy LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: | basal cell carcinoma, immunotherapy, tumor mutational burden, pd-1, pd-l1, checkpoint blockade, biomarkers, therapeutic antibodies, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: | Metastatic basal cell cancer (BCC) is an ultra-rare malignancy with no approved therapies beyond Hedgehog inhibitors. We characterized the genomics, tumor mutational burden (TMB), and anti-PD-1 therapy responses in patients with locally advanced or metastatic BCC. Overall, 2,039 diverse cancer samples that had undergone comprehensive genomic profiling (CGP) were reviewed. Eight patients with locally advanced/metastatic BCC were identified (two had two CGP analyses; total, 10 biopsies). Two tumors demonstrated PD-L1 amplification. Seven patients had >1 actionable alteration. The TMB (mutations/mb) (median (range)) was 90 (3-103) for the BCCs versus 4 (1-860) for 1637 cancers other than BCC (P < 0.0001). Median progression-free survival (PFS) for all four patients treated with PD-1 blockade was 10.7 months (range, 3.8 to 17.6+ months); three patients had an objective response. In conclusion, advanced/metastatic BCC often has biological features (high TMB; PD-L1 amplification) predictive of immunotherapy benefit, and patients frequently respond to PD-1 blockade. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2162-402X 2162402X |
| Relation: | https://doaj.org/toc/2162-402X |
| DOI: | 10.1080/2162402X.2017.1404217 |
| Access URL: | https://doaj.org/article/87de5ce678674a5a8eb59c501286191b |
| Accession Number: | edsdoj.87de5ce678674a5a8eb59c501286191b |
| Database: | Directory of Open Access Journals |
| ISSN: | 2162402X |
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| DOI: | 10.1080/2162402X.2017.1404217 |
| Published in: | OncoImmunology |
| Language: | English |