Bibliographic Details
| Title: |
Baseline echocardiographic variables as predictors of hemodynamically significant cytokine release syndrome in adults treated with CD19 CAR T-cell therapy for hematological malignancies |
| Authors: |
Andres E. Daryanani, Muhannad A. Abbasi, Maria F. Gomez Ardila, Eduardo Tellez-Garcia, Juan M. Garzon-Dangond, Yi Lin, Jonas Paludo, Joerg Herrmann, Stephen M. Ansell, Allison C. Rosenthal, Hector R. Villarraga |
| Source: |
Cardio-Oncology, Vol 10, Iss 1, Pp 1-11 (2024) |
| Publisher Information: |
BMC, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Diseases of the circulatory (Cardiovascular) system
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
Echocardiography, Chimeric antigen T-cell therapy, B-cell lymphoma, Cytokine release syndrome, Cancer therapy-related cardiac dysfunction, Cardiotoxicity, Diseases of the circulatory (Cardiovascular) system, RC666-701, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
Abstract Background CD19 CAR T-cell therapy is a novel anti-cancer treatment that has produced remarkable responses in relapsed or refractory B-cell hematological malignancies. Cytokine Release Syndrome (CRS) is a dysregulated immune response that frequently occurs after CAR T-cell infusion. It can cause cardiac dysfunction and circulatory collapse negatively impacting outcomes and survival. To endure the insults of CRS, patients are typically screened for adequate cardiac reserve before treatment. The relationship between baseline cardiac function by echocardiography and the development of moderate to severe presentations of CRS is unclear. Methods This study aimed to identify baseline echocardiographic variables that can predict the development of hemodynamically significant CRS (CRS ≥ 2), evaluate their behavior at follow-up, and investigate the incidence of cancer therapy-related cardiac dysfunction (CTRCD). An observational retrospective cohort study of patients treated with CD19 CAR T-cell therapy with a baseline echocardiogram was performed. Demographic, clinical and echocardiographic variables were abstracted from the electronic health record. Patients were grouped and compared by the occurrence of CRS |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2057-3804 |
| Relation: |
https://doaj.org/toc/2057-3804 |
| DOI: |
10.1186/s40959-024-00290-6 |
| Access URL: |
https://doaj.org/article/87cebc1b5f8047e184905b24b3b31df9 |
| Accession Number: |
edsdoj.87cebc1b5f8047e184905b24b3b31df9 |
| Database: |
Directory of Open Access Journals |
