Bibliographic Details
| Title: |
Arecoline-Induced Hepatotoxicity in Rats: Screening of Abnormal Metabolic Markers and Potential Mechanisms |
| Authors: |
Jing Sun, Kai Zhang, Yihui Yin, Yunpeng Qi, Siyuan Li, Haonan Sun, Min Luo, Yixuan Sun, Zhiying Yu, Jie Yang, Jingjing Wu, Lijuan Chen, Wenjuan Xu, Ling Dong |
| Source: |
Toxics, Vol 11, Iss 12, p 984 (2023) |
| Publisher Information: |
MDPI AG, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Chemical technology |
| Subject Terms: |
Arecoline, hepatotoxicity, metabolomics, network toxicology, Chemical technology, TP1-1185 |
| More Details: |
Arecoline is a pyridine alkaloid derived from areca nut in the Arecaceae family. It has extensive medicinal activity, such as analgesic, anti-inflammatory, and anti-allergic. However, the toxicity of Arecoline limits its application. Most current studies on its toxicity mainly focus on immunotoxicity, carcinogenesis, and cancer promotion. However, there are few systematic studies on its hepatotoxicity and mechanisms. Therefore, this research explored the mechanism of hepatotoxicity induced by Arecoline in rats and analyzed endogenous metabolite changes in rat plasma by combining network toxicology with metabolomics. The differential metabolites after Arecoline exposure, such as D-Lysine, N4-Acetylaminobutanal, and L-Arginine, were obtained by metabolomics study, and these differential metabolites were involved in the regulation of lipid metabolism, amino acid metabolism, and vitamin metabolism. Based on the strategy of network toxicology, Arecoline can affect the HIF-1 signaling pathway, MAPK signaling pathway, PI3K-Akt signaling pathway, and other concerning pathways by regulating critical targets, such as ALB, CASP3, EGFR, and MMP9. Integration of metabolomics and network toxicology results were further analyzed, and it was concluded that Arecoline may induce hepatotoxicity by mediating oxidative stress, inflammatory response, energy and lipid metabolism, and cell apoptosis. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2305-6304 |
| Relation: |
https://www.mdpi.com/2305-6304/11/12/984; https://doaj.org/toc/2305-6304 |
| DOI: |
10.3390/toxics11120984 |
| Access URL: |
https://doaj.org/article/87c62647be944cb183b743a57ad036ca |
| Accession Number: |
edsdoj.87c62647be944cb183b743a57ad036ca |
| Database: |
Directory of Open Access Journals |
