Academic Journal
The efficacy of 18F-FDG PET/CT and 67Ga SPECT/CT in diagnosing fever of unknown origin
| Title: | The efficacy of 18F-FDG PET/CT and 67Ga SPECT/CT in diagnosing fever of unknown origin |
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| Authors: | Bor-Tau Hung, Pei-Wen Wang, Yu-Jih Su, Wen-Chi Huang, Yen-Hsiang Chang, Shu-Hua Huang, Chiung-Chih Chang |
| Source: | International Journal of Infectious Diseases, Vol 62, Iss C, Pp 10-17 (2017) |
| Publisher Information: | Elsevier, 2017. |
| Publication Year: | 2017 |
| Collection: | LCC:Infectious and parasitic diseases |
| Subject Terms: | 18F-FDG PET/CT, 67Ga SPECT/CT, Fever of unknown origin, Infectious and parasitic diseases, RC109-216 |
| More Details: | Objective: Fever of unknown origin (FUO) is a diagnostic challenge. This study aimed to assess the efficacy of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) and gallium-67 single-photon emission computed tomography/computed tomography (67Ga SPECT/CT) in diagnosing FUO. Methods: A total of 68 patients with FUO underwent 18F-FDG PET/CT and 67Ga SPECT/CT from January 2013 through May 2016. Images were read independently. The imaging results were compared with the final diagnosis and categorized as helpful for diagnosis or non-contributory to diagnosis in the clinical setting. Associations between categorical variables were evaluated with the chi-square test or Fisher’s exact test. Results: Ten of the 68 patients were excluded. An infectious underlying disease was found in 23 patients. A malignant disorder was the cause of FUO in 10 patients. Non-infectious inflammatory disease was found in 11 patients. Adrenal insufficiency was the cause of FUO in two patients. The cause of FUO was not found for 12 patients. A high false-positive rate of 44% (7/16) was observed for 18F-FDG PET/CT, while a high false-negative rate of 55% (23/42) was observed for 67Ga SPECT/CT. 18F-FDG PET/CT studies depicted all 67Ga-avid lesions. The sensitivity (79% vs. 45%) and clinical contribution (72% vs. 55%) of 18F-FDG PET/CT in diagnosing FUO were significantly higher than those of 67Ga SPECT/CT (p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1201-9712 1878-3511 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S120197121730173X; https://doaj.org/toc/1201-9712; https://doaj.org/toc/1878-3511 |
| DOI: | 10.1016/j.ijid.2017.06.019 |
| Access URL: | https://doaj.org/article/d87c23fa4fa54bed9a047980b8acae2a |
| Accession Number: | edsdoj.87c23fa4fa54bed9a047980b8acae2a |
| Database: | Directory of Open Access Journals |
| ISSN: | 12019712 18783511 |
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| DOI: | 10.1016/j.ijid.2017.06.019 |
| Published in: | International Journal of Infectious Diseases |
| Language: | English |