Academic Journal
Calming the (Cytokine) Storm: Dimethyl Fumarate as a Therapeutic Candidate for COVID-19
| Title: | Calming the (Cytokine) Storm: Dimethyl Fumarate as a Therapeutic Candidate for COVID-19 |
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| Authors: | Cara A. Timpani, Emma Rybalka |
| Source: | Pharmaceuticals, Vol 14, Iss 1, p 15 (2020) |
| Publisher Information: | MDPI AG, 2020. |
| Publication Year: | 2020 |
| Collection: | LCC:Medicine LCC:Pharmacy and materia medica |
| Subject Terms: | COVID-19, dimethyl fumarate, Nrf2, therapeutics, Medicine, Pharmacy and materia medica, RS1-441 |
| More Details: | COVID-19 has rapidly spread worldwide and incidences of hospitalisation from respiratory distress are significant. While a vaccine is in the pipeline, there is urgency for therapeutic options to address the immune dysregulation, hyperinflammation and oxidative stress that can lead to death. Given the shared pathogenesis of severe cases of COVID-19 with aspects of multiple sclerosis and psoriasis, we propose dimethyl fumarate as a viable treatment option. Currently approved for multiple sclerosis and psoriasis, dimethyl fumarate is an immunomodulatory, anti-inflammatory and anti-oxidative drug that could be rapidly implemented into the clinic to calm the cytokine storm which drives severe COVID-19. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1424-8247 |
| Relation: | https://www.mdpi.com/1424-8247/14/1/15; https://doaj.org/toc/1424-8247 |
| DOI: | 10.3390/ph14010015 |
| Access URL: | https://doaj.org/article/e86ffdad3262428b8222487edc2b50ef |
| Accession Number: | edsdoj.86ffdad3262428b8222487edc2b50ef |
| Database: | Directory of Open Access Journals |
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| ISSN: | 14248247 |
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| DOI: | 10.3390/ph14010015 |
| Published in: | Pharmaceuticals |
| Language: | English |