| Title: |
Factors associated with the compensation of renal function after nephrectomy of a kidney donor |
| Authors: |
Carla Burballa, Marta Crespo, Dolores Redondo-Pachón, María José Pérez-Sáez, Carlos Arias-Cabrales, Marisa Mir, Albert Francés, Lluís Fumadó, Lluís Cecchini, Julio Pascual |
| Source: |
Nefrología (English Edition), Vol 38, Iss 5, Pp 528-534 (2018) |
| Publisher Information: |
Elsevier, 2018. |
| Publication Year: |
2018 |
| Collection: |
LCC:Diseases of the genitourinary system. Urology |
| Subject Terms: |
Diseases of the genitourinary system. Urology, RC870-923 |
| More Details: |
Introduction: Kidney transplant donors lose 50% of their renal mass after nephrectomy. The remaining kidney compensates for this loss and it is estimated that 70% of the baseline renal function prior to donation is recovered. Factors associated with post-donation renal compensation are not well understood. Methods: Retrospective study of 66 consecutive kidney donors (mean age 48.8 years, 74.2% women). We analyzed the potential factors associated with the compensatory mechanisms of the remaining kidney by comparing donors according to their renal compensation rate (RCR) (Group A, infra-compensation [70%]). Results: We compared Group A (n = 38) and group B (n = 28). Predictors for RCR > 70% were higher baseline creatinine (A vs. B: 0.73 ± 0.14 vs. 0.82 ± 0.11; p = 0.03) and a lower baseline glomerular filtration rate (GFR), estimated both by MDRD-4 (A vs. B: 97.7 ± 18.8 vs. 78.6 ± 9.6 ml/min; p 70% compensation (MDRD-4, OR = 0.94 [95% CI 0.8–0.9], p = 0.01). The compensation rate decreased by 0.4% (p 70%]). Resultados: Comparamos los grupos A (n = 38) y B (n = 28). Los factores predictores de una TCR > 70% fueron una mayor creatinina basal (A vs. B 0,73 ± 0,14 vs. 0,82 ± 0,11; p = 0,03) y menor filtrado glomerular (FG), tanto estimado mediante MDRD-4 (A vs. B 97,7 ± 18,8 vs. 78,6 ± 9,6 ml/min; p 70% (MDRD-4, odds ratio [OR] = 0,94 [IC 95%: 0,8-0,9], p = 0,01). La tasa de compensación era 0,4% (p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2013-2514 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2013251418301093; https://doaj.org/toc/2013-2514 |
| DOI: |
10.1016/j.nefroe.2018.10.002 |
| Access URL: |
https://doaj.org/article/86f14ccafd0248e695ddd6e473956e61 |
| Accession Number: |
edsdoj.86f14ccafd0248e695ddd6e473956e61 |
| Database: |
Directory of Open Access Journals |
