Bifidobacterium alleviate metabolic disorders via converting methionine to 5’-methylthioadenosine
| Title: | Bifidobacterium alleviate metabolic disorders via converting methionine to 5’-methylthioadenosine |
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| Authors: | Qiang Lyu, Rou-An Chen, Hsiao-Li Chuang, Hsin-Bai Zou, Lihong Liu, Li-Kang Sung, Po-Yu Liu, Hsin-Yi Wu, Hsin-Yuan Chang, Wan-Ju Cheng, Wei-Kai Wu, Ming-Shiang Wu, Cheng-Chih Hsu |
| Source: | Gut Microbes, Vol 16, Iss 1 (2024) |
| Publisher Information: | Taylor & Francis Group, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Diseases of the digestive system. Gastroenterology |
| Subject Terms: | Bifidobacterium, 5’-methylthioadenosine, LC-MS/MS metabolomics, probiotic, prebiotic, postbiotic, Diseases of the digestive system. Gastroenterology, RC799-869 |
| More Details: | ABSTRACTDietary patterns and corresponding gut microbiota profiles are associated with various health conditions. A diet rich in polyphenols, primarily plant-based, has been shown to promote the growth of probiotic bacteria in the gastrointestinal tract, subsequently reducing the risk of metabolic disorders in the host. The beneficial effects of these bacteria are largely due to the specific metabolites they produce, such as short-chain fatty acids and membrane proteins. In this study, we employed a metabolomics-guided bioactive metabolite identification platform that included bioactivity testing using in vitro and in vivo assays to discover a bioactive metabolite produced from probiotic bacteria. Through this approach, we identified 5’-methylthioadenosine (MTA) as a probiotic bacterial-derived metabolite with anti-obesity properties. Furthermore, our findings indicate that MTA administration has several regulatory impacts on liver functions, including modulating fatty acid synthesis and glucose metabolism. The present study elucidates the intricate interplay between dietary habits, gut microbiota, and their resultant metabolites. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 19490976 1949-0984 1949-0976 |
| Relation: | https://doaj.org/toc/1949-0976; https://doaj.org/toc/1949-0984 |
| DOI: | 10.1080/19490976.2023.2300847 |
| Access URL: | https://doaj.org/article/86dca9a746a54a6888601f6719d34083 |
| Accession Number: | edsdoj.86dca9a746a54a6888601f6719d34083 |
| Database: | Directory of Open Access Journals |
| ISSN: | 19490976 19490984 |
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| DOI: | 10.1080/19490976.2023.2300847 |
| Published in: | Gut Microbes |
| Language: | English |