Bibliographic Details
| Title: |
Neutrophil elastase inhibitor (Sivelestat) in the treatment of acute respiratory distress syndrome induced by COVID-19: a multicenter retrospective cohort study |
| Authors: |
Yuting Li, Jianjun Zhao, Jiahui Wei, Yanhong Zhang, Haitao Zhang, Ying Li, Ting Liao, Yang Hu, Bo Yuan, Xinmei Zhang, Wanyan Liu, Changgang Liu, Qingsong Cui, Shunzi Wu, Hongmei Jiang, Wenge Liu, Weiheng Liu, Hongguang Xu, Gang Li, Yuyan Cai, Liting Chen, Bingwei Chen, Dong Zhang |
| Source: |
Respiratory Research, Vol 26, Iss 1, Pp 1-10 (2025) |
| Publisher Information: |
BMC, 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Diseases of the respiratory system |
| Subject Terms: |
Acute respiratory distress syndrome, COVID-19, Neutrophil elastase, Sivelestat, Survival, Diseases of the respiratory system, RC705-779 |
| More Details: |
Abstract Background Recent studies suggest that neutrophil elastase inhibitor (Sivelestat) may improve pulmonary function and reduce mortality in patients with acute respiratory distress syndrome. We examined the association between receipt of sivelestat and improvement in oxygenation among patients with acute respiratory distress syndrome (ARDS) induced by COVID-19. Methods A large multicentre cohort study of patients with ARDS induced by COVID-19 who had been admitted to intensive care units (ICUs). We used propensity score matching to compare the outcomes of patients treated with sivelestat to those who were not. The differences in continuous outcomes were assessed with the Wilcoxon signed-rank test. Kaplan–Meier method was used to show the 28-day survival curves in the matched cohorts. A log-rank P-test stratified on the matched pairs was used to test the equality of the estimated survival curves. A Cox proportional hazards model that incorporated a robust sandwich-type variance estimator to account for the matched nature of the data was used to estimate hazard ratios (HR). All statistical analyses were performed with SPSS 26.0 and R 4.2.3. A two-sided p-value of |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1465-993X |
| Relation: |
https://doaj.org/toc/1465-993X |
| DOI: |
10.1186/s12931-025-03100-4 |
| Access URL: |
https://doaj.org/article/86da30da7c0a4af89474906ec59a0510 |
| Accession Number: |
edsdoj.86da30da7c0a4af89474906ec59a0510 |
| Database: |
Directory of Open Access Journals |
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