Bibliographic Details
| Title: |
Passion fruit peel fermentation extract and its active component kaempferol alleviate constipation and hemorrhoids in mice by downregulating ESR1 and PI3K/Akt pathways |
| Authors: |
Xiaotian Xu, Xinhui Li, Xingshu Wei, Xiaoqun Duan, Yuhui Wang |
| Source: |
Journal of Functional Foods, Vol 115, Iss , Pp 106112- (2024) |
| Publisher Information: |
Elsevier, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Nutrition. Foods and food supply |
| Subject Terms: |
Passion fruit peel fermentation extract, Kaempferol, Constipation, Hemorrhoids, ESR1, PI3K/Akt, Nutrition. Foods and food supply, TX341-641 |
| More Details: |
Passion fruit peel fermentation extract (PFPFE) increased gastrointestinal transport power and fecal moisture content, protected the structural integrity of colon tissue, and reduced inflammatory infiltration. PFPFE also increased secretion of the ET-1, GAS, MTL, and SP, and decreased secretion of the inhibitory SS and VIP. In addition, PFPFE alleviated perirectal redness and hemorrhage in hemorrhoid mice, and downregulated levels of the serum inflammatory factors tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β). In this study, we also analyzed the main active components and core targets of PFPFE for alleviating constipation and hemorrhoids through network pharmacology, and predicted its mechanism of action. Finally, we carried out Western blot experiments to verify that PFPFE and its active component kae alleviates constipation and hemorrhoids in mice by downregulating ESR1 and PI3K/Akt pathways. These results provide a scientific basis for the development of PFPFE as a functional food for alleviating constipation and hemorrhoids. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1756-4646 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1756464624001142; https://doaj.org/toc/1756-4646 |
| DOI: |
10.1016/j.jff.2024.106112 |
| Access URL: |
https://doaj.org/article/a869d597055c42efbcf668215f273041 |
| Accession Number: |
edsdoj.869d597055c42efbcf668215f273041 |
| Database: |
Directory of Open Access Journals |
