Bibliographic Details
| Title: |
Kynurenine pathway in Parkinson's disease—An update |
| Authors: |
Dhivya Venkatesan, Mahalaxmi Iyer, Arul Narayanasamy, Kamalakannan Siva, Balachandar Vellingiri |
| Source: |
eNeurologicalSci, Vol 21, Iss , Pp 100270- (2020) |
| Publisher Information: |
Elsevier, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Neurology. Diseases of the nervous system |
| Subject Terms: |
Ageing, Biomarkers, Kynurenine pathway (KP), Parkinson's disease (PD), Therapeutics, Neurology. Diseases of the nervous system, RC346-429 |
| More Details: |
Parkinson's disease (PD) is a complex multi-factorial neurodegenerative disorder where various altered metabolic pathways contribute to the progression of the disease. Tryptophan (TRP) is a major precursor in kynurenine pathway (KP) and it has been discussed in various in vitro studies that the metabolites quinolinic acid (QUIN) causes neurotoxicity and kynurenic acid (KYNA) acts as neuroprotectant respectively. More studies are also focused on the effects of other KP metabolites and its enzymes as it has an association with ageing and PD pathogenesis. Until now, very few studies have targeted the role of genetic mutations in abnormal KP metabolism in adverse conditions of PD. Therefore, the present review gives an updated research studies on KP in connection with PD. Moreover, the review emphasizes on the urge for the development of biomarkers and also this would be an initiative in generating an alternative therapeutic approach for PD. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2405-6502 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2405650220300496; https://doaj.org/toc/2405-6502 |
| DOI: |
10.1016/j.ensci.2020.100270 |
| Access URL: |
https://doaj.org/article/d86375c13cac4746bf2edfcc835c3fc0 |
| Accession Number: |
edsdoj.86375c13cac4746bf2edfcc835c3fc0 |
| Database: |
Directory of Open Access Journals |
