Bibliographic Details
| Title: |
Use of bee venom in preventive medicine: An experimental hepatic encephalopathy study in rats |
| Authors: |
Mustafa Bayraktar, Ahmet Hacımüftüoğlu, Ufuk Okkay, Mehmet Nuri Koçak, Murat Kösedağ, Erdal Tekin, Muhammet Çelik, Irmak Ferah Okkay, Cemil Bayram, Muhammet Sait Ertuğrul, Selma Sezen |
| Source: |
Veterinary Medicine and Science, Vol 10, Iss 1, Pp n/a-n/a (2024) |
| Publisher Information: |
Wiley, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Veterinary medicine |
| Subject Terms: |
Bee venom, hepatic encephalopathy, prevention, primary care, Veterinary medicine, SF600-1100 |
| More Details: |
Abstract Objectives Bee venom is used for medicinal purposes, including the treatment of neurological and liver diseases, but its use as a primary health care approach for preventive purposes requires further exploration. The aim of this study was to provide the first investigation into the possible protective effects of bee venom against hepatic encephalopathy, a serious neurodegenerative disease. Materials and Methods An experimental animal study was conducted in which healthy albino Sprague–Dawley rats were randomized into three groups: healthy, control and bee venom groups. All rats were tested for locomotor activity at the beginning and end of the study. No intervention was made in the healthy group, whereas hepatic encephalopathy was induced in the control and bee venom groups by the administration of thioacetamide (TAA) (200 mg/kg/day). The bee venom group also received bee venom (5 mg/kg/day) subcutaneously every day for 14 days prior to the TAA administration. Results The results for the final locomotor activity tests were statistically better in the bee venom group than in the control group, supporting a beneficial effect of prophylactic bee venom application. Blood ammonia levels and liver weights, determined as indicators of inflammation, were lower in the bee venom group than in the control group and were close to levels in the healthy group, but not statistically significant. Conclusions Bee venom administration has protective effects against the development of hepatic encephalopathy and offers a promising therapeutic opportunity in preventive medicine. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2053-1095 |
| Relation: |
https://doaj.org/toc/2053-1095 |
| DOI: |
10.1002/vms3.1336 |
| Access URL: |
https://doaj.org/article/861f93930f8b4846aa29dc0d2361623f |
| Accession Number: |
edsdoj.861f93930f8b4846aa29dc0d2361623f |
| Database: |
Directory of Open Access Journals |
