Academic Journal
Immune Response to Rotavirus and Gluten Sensitivity
| Title: | Immune Response to Rotavirus and Gluten Sensitivity |
|---|---|
| Authors: | Antonio Puccetti, Daniele Saverino, Roberta Opri, Oretta Gabrielli, Giovanna Zanoni, Andrea Pelosi, Piera Filomena Fiore, Francesca Moretta, Claudio Lunardi, Marzia Dolcino |
| Source: | Journal of Immunology Research, Vol 2018 (2018) |
| Publisher Information: | Hindawi Limited, 2018. |
| Publication Year: | 2018 |
| Collection: | LCC:Immunologic diseases. Allergy |
| Subject Terms: | Immunologic diseases. Allergy, RC581-607 |
| More Details: | Rotavirus is a double-stranded RNA virus belonging to the family of Reoviridae. The virus is transmitted by the faecal-oral route and infects intestinal cells causing gastroenteritis. Rotaviruses are the main cause of severe acute diarrhoea in children less than 5 years of age worldwide. In our previous work we have shown a link between rotavirus infection and celiac disease. Nonceliac gluten sensitivity (NCGS) is emerging as new clinical entity lacking specific diagnostic biomarkers which has been reported to occur in 6–10% of the population. Clinical manifestations include gastrointestinal and/or extraintestinal symptoms which recede with gluten withdrawal. The pathogenesis of the disease is still unknown. Aim of this work is to clarify some aspects of its pathogenesis using a gene array approach. Our results suggest that NCGS may have an autoimmune origin. This is based both on gene expression data (i.e., TH17-interferon signatures) and on the presence of TH17 cells and of serological markers of autoimmunity in NCGS. Our results also indicate a possible involvement of rotavirus infection in the pathogenesis of nonceliac gluten sensitivity similarly to what we have previously shown in celiac disease. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2314-8861 2314-7156 |
| Relation: | https://doaj.org/toc/2314-8861; https://doaj.org/toc/2314-7156 |
| DOI: | 10.1155/2018/9419204 |
| Access URL: | https://doaj.org/article/8617844af3f248e2b3b5982e176dfbc2 |
| Accession Number: | edsdoj.8617844af3f248e2b3b5982e176dfbc2 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 23148861 23147156 |
|---|---|
| DOI: | 10.1155/2018/9419204 |
| Published in: | Journal of Immunology Research |
| Language: | English |