Differential expression of miR-1297, miR-3191-5p, miR-4435, and miR-4465 in malignant and benign breast tumors
| Title: | Differential expression of miR-1297, miR-3191-5p, miR-4435, and miR-4465 in malignant and benign breast tumors |
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| Authors: | Abbas Mosapour, Fatemeh Soghra Karami Tehrani, Morteza Atri |
| Source: | Iranian Journal of Basic Medical Sciences, Vol 23, Iss 8, Pp 1045-1052 (2020) |
| Publisher Information: | Mashhad University of Medical Sciences, 2020. |
| Publication Year: | 2020 |
| Collection: | LCC:Medicine |
| Subject Terms: | biomarker, breast cancer, diagnosis, mir (microrna), oncomir, Medicine |
| More Details: | Objective(s): MicroRNAs (miRs) are a class of small non-coding RNAs which are associated with tumor growth and progression. In the present study, we assessed the expression of selected miRs in malignant, benign, and adjacent normal breast tissues. Materials and Methods: The expression of miR-1297, miR-3191-5P, miR-4435, and miR-4465 were evaluated in malignant (n=50), benign (n=35), and adjacent normal breast tissues (n=20) using qRT-PCR. Receiver operating characteristic curves and the area under the ROC curve and AUC were generated for evaluating the diagnostic values of miRs. To evaluate diagnostic efficacy, miRs-based score was obtained using the logistic regression model. Results: Among malignant tumors, the expression of miR-1297, miR-3191-5p, and miR-4435 was significantly lower (P=0.024, PConclusion: The panel of these miRs are suggested as possible onco-miRs(miR-4465) or tumor suppressor-miRs (miR-3191-5P, miR-1297, miR-4435). Overall, our results indicated that these miRs could be introduced as diagnostic biomarkers in breast cancer patients. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2008-3866 2008-3874 |
| Relation: | http://ijbms.mums.ac.ir/article_15703_46b48a69cb124ab35800f339aca8319a.pdf; https://doaj.org/toc/2008-3866; https://doaj.org/toc/2008-3874 |
| DOI: | 10.22038/ijbms.2020.44581.10421 |
| Access URL: | https://doaj.org/article/a8615cb9dd0049ef91a3fbe1a2205e8a |
| Accession Number: | edsdoj.8615cb9dd0049ef91a3fbe1a2205e8a |
| Database: | Directory of Open Access Journals |
| ISSN: | 20083866 20083874 |
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| DOI: | 10.22038/ijbms.2020.44581.10421 |
| Published in: | Iranian Journal of Basic Medical Sciences |
| Language: | English |