| Title: |
Case report: Hemorrhagic fever with renal syndrome presenting as hemophagocytic lymphohistiocytosis |
| Authors: |
Maarten A. J. De Smet, Simon Bogaert, Alexander Schauwvlieghe, Amélie Dendooven, Pieter Depuydt, Patrick Druwé |
| Source: |
Frontiers in Medicine, Vol 9 (2022) |
| Publisher Information: |
Frontiers Media S.A., 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Medicine (General) |
| Subject Terms: |
hemophagocytic lymphohistiocytosis, hemorrhagic fever with renal syndrome, hantavirus, critical care, communicable diseases Puumala virus-associated hemophagocytosis, Medicine (General), R5-920 |
| More Details: |
Hemophagocytic lymphohistiocytosis may occur in patients with genetic predisposition and in sporadic cases due to malignancy or infection. We describe a 49-year old man with hemorrhagic fever, type 1 respiratory insufficiency and acute kidney injury. Diagnostic work up showed a hyperinflammatory syndrome, hypertriglyceridemia, hemophagocytosis, very high ferritin and significantly elevated sCD25. The findings were compatible with hemophagocytic lymphohistiocytosis based on the HLH-2004 criteria. Serological testing indentified Puumala virus as the causal pathogen. The patient was successfully treated with pulse corticosteroids, intravenous immunoglobins and supportive therapy. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2296-858X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fmed.2022.1096900/full; https://doaj.org/toc/2296-858X |
| DOI: |
10.3389/fmed.2022.1096900 |
| Access URL: |
https://doaj.org/article/85477b4ae5204370a46bbfe6699aaa47 |
| Accession Number: |
edsdoj.85477b4ae5204370a46bbfe6699aaa47 |
| Database: |
Directory of Open Access Journals |
