Academic Journal
Body mass index but not genetic risk is longitudinally associated with altered structural brain parameters
| Title: | Body mass index but not genetic risk is longitudinally associated with altered structural brain parameters |
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| Authors: | Anne Tüngler, Sandra Van der Auwera, Katharina Wittfeld, Stefan Frenzel, Jan Terock, Nele Röder, Georg Homuth, Henry Völzke, Robin Bülow, Hans Jörgen Grabe, Deborah Janowitz |
| Source: | Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) |
| Publisher Information: | Nature Portfolio, 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Medicine LCC:Science |
| Subject Terms: | Medicine, Science |
| More Details: | Abstract Evidence from previous studies suggests that elevated body mass index (BMI) and genetic risk for obesity is associated with reduced brain volume, particularly in areas of reward-related cognition, e.g. the medial prefrontal cortex (AC-MPFC), the orbitofrontal cortex (OFC), the striatum and the thalamus. However, only few studies examined the interplay between these factors in a joint approach. Moreover, previous findings are based on cross-sectional data. We investigated the longitudinal relationship between increased BMI, brain structural magnetic resonance imaging (MRI) parameters and genetic risk scores in a cohort of n = 502 community-dwelling participants from the Study of Health in Pomerania (SHIP) with a mean follow-up-time of 4.9 years. We found that (1) increased BMI values at baseline were associated with decreased brain parameters at follow-up. These effects were particularly pronounced for the OFC and AC-MPFC. (2) The genetic predisposition for BMI had no effect on brain parameters at baseline or follow-up. (3) The interaction between the genetic score for BMI and brain parameters had no effect on BMI at baseline. Finding a significant impact of overweight, but not genetic predisposition for obesity on altered brain structure suggests that metabolic mechanisms may underlie the relationship between obesity and altered brain structure. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-021-03343-3 |
| Access URL: | https://doaj.org/article/84d477d626064ea2b1fcdf58b4fcc10e |
| Accession Number: | edsdoj.84d477d626064ea2b1fcdf58b4fcc10e |
| Database: | Directory of Open Access Journals |
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| ISSN: | 20452322 |
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| DOI: | 10.1038/s41598-021-03343-3 |
| Published in: | Scientific Reports |
| Language: | English |