Academic Journal
Exploring HIV infection and susceptibility to measles among older children and adults in Malawi: a facility-based study
| Title: | Exploring HIV infection and susceptibility to measles among older children and adults in Malawi: a facility-based study |
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| Authors: | Jonathan A. Polonsky, Beverley Singh, Charlie Masiku, Céline Langendorf, Matthew Kagoli, Northan Hurtado, Mathilde Berthelot, Annette Heinzelmann, Adrian Puren, Rebecca F. Grais |
| Source: | International Journal of Infectious Diseases, Vol 31, Iss C, Pp 61-67 (2015) |
| Publisher Information: | Elsevier, 2015. |
| Publication Year: | 2015 |
| Collection: | LCC:Infectious and parasitic diseases |
| Subject Terms: | Measles, HIV, Malawi, Vaccination, CD4, IgG, Infectious and parasitic diseases, RC109-216 |
| More Details: | Background: HIV infection increases measles susceptibility in infants, but little is known about this relationship among older children and adults. We conducted a facility-based study to explore whether HIV status and/or CD4 count were associated with either measles seroprotection and/or measles antibody concentration. Methods: A convenience sample was recruited comprising HIV-infected patients presenting for follow-up care, and HIV-uninfected individuals presenting for HIV testing at Chiradzulu District Hospital, Malawi, from January to September 2012. We recorded age, sex, and reported measles vaccination and infection history. Blood samples were taken to determine the CD4 count and measles antibody concentration. Results: One thousand nine hundred and thirty-five participants were recruited (1434 HIV-infected and 501 HIV-uninfected). The majority of adults and approximately half the children were seroprotected against measles, with lower odds among HIV-infected children (adjusted odds ratio 0.27, 95% confidence interval 0.10–0.69; p = 0.006), but not adults. Among HIV-infected participants, neither CD4 count (p = 0.16) nor time on antiretroviral therapy (p = 0.25) were associated with measles antibody concentration, while older age (p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1201-9712 1878-3511 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S1201971214017275; https://doaj.org/toc/1201-9712; https://doaj.org/toc/1878-3511 |
| DOI: | 10.1016/j.ijid.2014.12.010 |
| Access URL: | https://doaj.org/article/84a23d27626c4a6981276b037c1dfbfb |
| Accession Number: | edsdoj.84a23d27626c4a6981276b037c1dfbfb |
| Database: | Directory of Open Access Journals |
| ISSN: | 12019712 18783511 |
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| DOI: | 10.1016/j.ijid.2014.12.010 |
| Published in: | International Journal of Infectious Diseases |
| Language: | English |