Bibliographic Details
| Title: |
Rapid spread of the SARS-CoV-2 Omicron XDR lineage derived from recombination between XBB and BA.2.86 subvariants circulating in Brazil in late 2023 |
| Authors: |
Ighor Arantes, Kimihito Ito, Marcelo Gomes, Felipe Cotrim de Carvalho, Walquiria Aparecida Ferreira de Almeida, Ricardo Khouri, Fabio Miyajima, Gabriel Luz Wallau, Felipe Gomes Naveca, Elisa Cavalcante Pereira, Marilda Mendonça Siqueira, Paola Cristina Resende, Gonzalo Bello |
| Source: |
Microbiology Spectrum, Vol 13, Iss 1 (2025) |
| Publisher Information: |
American Society for Microbiology, 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Microbiology |
| Subject Terms: |
SARS-CoV-2, XDR, Brazil, recombination, phylogeography, Microbiology, QR1-502 |
| More Details: |
ABSTRACT Recombination plays a crucial role in the evolution of SARS-CoV-2. The Omicron XBB* recombinant lineages are a noteworthy example, as they have been the dominant SARS-CoV-2 variant worldwide in the first half of 2023. Since November 2023, a new recombinant lineage between Omicron subvariants XBB and BA.2.86, designated XDR, has been detected mainly in Brazil. In this study, we reconstructed the spatiotemporal dynamics and estimated the absolute and relative transmissibility of the XDR lineage. The XDR lineage displayed a recombination breakpoint in the ORF1a-coding region, and the most closely related sequences to the 5′ and 3′ ends of the recombinant correspond to JD.1.1 and JN.1.1 lineages, respectively. The first XDR sequences were detected in November 2023 in the Northeastern Brazilian region, and their prevalence rapidly surged from |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2165-0497 |
| Relation: |
https://doaj.org/toc/2165-0497 |
| DOI: |
10.1128/spectrum.01193-24 |
| Access URL: |
https://doaj.org/article/84758870fbfd4229aa134e362c95e792 |
| Accession Number: |
edsdoj.84758870fbfd4229aa134e362c95e792 |
| Database: |
Directory of Open Access Journals |
