| Title: |
Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds |
| Authors: |
Sara Campinoti, Asllan Gjinovci, Roberta Ragazzini, Luca Zanieri, Linda Ariza-McNaughton, Marco Catucci, Stefan Boeing, Jong-Eun Park, John C. Hutchinson, Miguel Muñoz-Ruiz, Pierluigi G. Manti, Gianluca Vozza, Carlo E. Villa, Demetra-Ellie Phylactopoulos, Constance Maurer, Giuseppe Testa, Hans J. Stauss, Sarah A. Teichmann, Neil J. Sebire, Adrian C. Hayday, Dominique Bonnet, Paola Bonfanti |
| Source: |
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020) |
| Publisher Information: |
Nature Portfolio, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
The thymus is essential for T cell maturation and selection, and thymic defects result in severe immune problems. Here the authors identify a thymus cell population that is expandable in vitro, and can repopulate natural thymic matrix to generate tissue that supports mature T cell development in vitro and in vivo. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-020-20082-7 |
| Access URL: |
https://doaj.org/article/c841855db99048c2a21529c2cdc906b1 |
| Accession Number: |
edsdoj.841855db99048c2a21529c2cdc906b1 |
| Database: |
Directory of Open Access Journals |
