Bibliographic Details
| Title: |
T cell related osteoimmunology in fracture healing: Potential targets for augmenting bone regeneration |
| Authors: |
Haixing Wang, Yashi Li, Haoxin Li, Xu Yan, Zhaowei Jiang, Lu Feng, Wenhui Hu, Yinuo Fan, Sien Lin, Gang Li |
| Source: |
Journal of Orthopaedic Translation, Vol 51, Iss , Pp 82-93 (2025) |
| Publisher Information: |
Elsevier, 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Diseases of the musculoskeletal system |
| Subject Terms: |
Bone formation, Fracture healing, Mesenchymal stem cell, Osteoimmunology, T cell, Diseases of the musculoskeletal system, RC925-935 |
| More Details: |
Last decade has witnessed increasing evidence which highlights the roles of immune cells in bone regeneration. Numerous immune cell types, including macrophages, T cells, and neutrophils are involved in fracture healing by orchestrating a series of events that modulate bone formation and remodeling. In this review, the role of T cell immunity in fracture healing has been summarized, and the modulatory effects of T cell immunity in inflammation, bone formation and remodeling have been highlighted. The review also summarizes the specific roles of different T cell subsets, including CD4+ T cells, CD8+ T cells, regulatory T cells, T helper 17 cells, and γδ T cells in modulating fracture healing. The current therapeutics targeting T cell immunity to enhance fracture healing have also been reviewed, aiming to provide insights from a translational standpoint. Overall, this work discusses recent advances and challenges in the interdisciplinary research field of T cell related osteoimmunology and its implications in fracture healing. The translational potential of this article: Delayed unions or non-unions of bone fractures remain a challenge in clinical practice. Developing a deep understanding of the roles of immune cells, including T cells, in fracture healing will facilitate the advancement of novel therapeutics of fracture nonunion. This review summarizes the current understanding of different T cell subsets involved in various phases of fracture healing, providing insights for targeting T cells as an alternative strategy to enhance bone regeneration. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2214-031X |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2214031X24001621; https://doaj.org/toc/2214-031X |
| DOI: |
10.1016/j.jot.2024.12.004 |
| Access URL: |
https://doaj.org/article/83f837de60a94addace1336f0920137c |
| Accession Number: |
edsdoj.83f837de60a94addace1336f0920137c |
| Database: |
Directory of Open Access Journals |
