Academic Journal
FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival
| Title: | FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival |
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| Authors: | Yuhui Kou, Zongxue Jin, Yusong Yuan, Bo Ma, Wenyong Xie, Na Han |
| Source: | Neural Regeneration Research, Vol 20, Iss 7, Pp 2108-2115 (2025) |
| Publisher Information: | Wolters Kluwer Medknow Publications, 2025. |
| Publication Year: | 2025 |
| Collection: | LCC:Neurology. Diseases of the nervous system |
| Subject Terms: | fk506, inflammation, motor neurons, nerve regeneration, neuron, peripheral nerve injury, sensory neurons, Neurology. Diseases of the nervous system, RC346-429 |
| More Details: | FK506 (Tacrolimus) is a systemic immunosuppressant approved by the U.S. Food and Drug Administration. FK506 has been shown to promote peripheral nerve regeneration, however, its precise mechanism of action and its pathways remain unclear. In this study, we established a rat model of sciatic nerve injury and found that FK506 improved the morphology of the injured sciatic nerve, increased the numbers of motor and sensory neurons, reduced inflammatory responses, markedly improved the conduction function of the injured nerve, and promoted motor function recovery. These findings suggest that FK506 promotes peripheral nerve structure recovery and functional regeneration by reducing the intensity of inflammation after neuronal injury and increasing the number of surviving neurons. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1673-5374 1876-7958 |
| Relation: | https://journals.lww.com/10.4103/NRR.NRR-D-22-00867; https://doaj.org/toc/1673-5374; https://doaj.org/toc/1876-7958 |
| DOI: | 10.4103/NRR.NRR-D-22-00867 |
| Access URL: | https://doaj.org/article/83d89c90b704460296d62643c7ce438c |
| Accession Number: | edsdoj.83d89c90b704460296d62643c7ce438c |
| Database: | Directory of Open Access Journals |
| ISSN: | 16735374 18767958 |
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| DOI: | 10.4103/NRR.NRR-D-22-00867 |
| Published in: | Neural Regeneration Research |
| Language: | English |