Academic Journal
CD8+ T-cells target the Crimean-Congo haemorrhagic fever virus Gc protein to control the infection in wild-type miceResearch in context
| Title: | CD8+ T-cells target the Crimean-Congo haemorrhagic fever virus Gc protein to control the infection in wild-type miceResearch in context |
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| Authors: | Deepashri Rao, Kimberly Meade-White, Shanna Leventhal, Evan Mihalakakos, Aaron Carmody, Heinz Feldmann, David W. Hawman |
| Source: | EBioMedicine, Vol 97, Iss , Pp 104839- (2023) |
| Publisher Information: | Elsevier, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Medicine LCC:Medicine (General) |
| Subject Terms: | Crimean-Congo haemorrhagic fever, CCHFV, T-cells, Mouse model, Adaptive immunity, Medicine, Medicine (General), R5-920 |
| More Details: | Summary: Background: Crimean-Congo haemorrhagic fever (CCHF) is a serious viral hemorrhagic fever caused by the CCHF virus (CCHFV). Spread by the bites of infected ticks or handling of viremic livestock, human disease is characterized by a non-specific febrile illness that can rapidly progress to fatal hemorrhagic disease. No vaccines or antivirals are available. Case fatality rates can vary but can be higher than 30%, although sub-clinical infections are often unrecognized and unreported. Yet, while most humans infected with CCHFV will survive the infection, often with little-to-no symptoms, the host responses that control the infection are unknown. Methods: Here we investigated the role of cellular immunity in control of CCHFV infection in an immunocompetent mouse model. Findings: We found that CD8+ T-cells are crucial for efficient control of the acute infection and rapidly acquired CCHFV-specific antiviral effector functions such as production of antiviral cytokines and degranulating in response to CCHFV peptides. We further identified the minimal CD8+ T-cell epitopes in the viral Gc proteins and that infection of mice lacking IFNγ resulted in worsened disease and higher viral loads. Interpretation: Together our data suggest that CD8+ T-cells are important for control of acute CCHFV infection likely through production of antiviral cytokines. Funding: This work was supported by the Intramural Research Program of the NIH. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2352-3964 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S235239642300405X; https://doaj.org/toc/2352-3964 |
| DOI: | 10.1016/j.ebiom.2023.104839 |
| Access URL: | https://doaj.org/article/8376ad720a87492293567c01503f90f0 |
| Accession Number: | edsdoj.8376ad720a87492293567c01503f90f0 |
| Database: | Directory of Open Access Journals |
| ISSN: | 23523964 |
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| DOI: | 10.1016/j.ebiom.2023.104839 |
| Published in: | EBioMedicine |
| Language: | English |