Bibliographic Details
| Title: |
No association between interleukin-18 levels and risk of cardiovascular disease: A Mendelian randomization study |
| Authors: |
Siyu Fan, Pan He, Jieqiong Guan, Wenjing Song, Hong Zhi, Lina Wang |
| Source: |
Hereditas, Vol 157, Iss 1, Pp 1-8 (2020) |
| Publisher Information: |
BMC, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Genetics |
| Subject Terms: |
IL-18 gene polymorphism, CVDs risk, Mendelian randomization, Meta-analysis, Genetics, QH426-470 |
| More Details: |
Abstract Objective In this study, Mendelian randomization method was used to determine whether there was a causal association between inflammatory cytokine IL-18 and cardiovascular disease risk. Methods We performed a meta-analysis to evaluate the association between IL-18-137G/C and -607C/A polymorphisms and phenotype of IL-18 levels, and also the risks of CVD. All the literatures were searched before September 30, 2019. The logistic regression and linear regression were used to evaluate between IL-18 level and the risk of CVDs. Result Twelve eligible articles of the association between IL-18-137G/C and CVD risks and 8 eligible literatures related to IL-18-607C/A and CVD risks; 2 qualified literatures of the association between IL-18 SNPs and IL-18 levels and 4 eligible literatures related to IL-18 levels and CVD risks. Data of 4 literatures on the correlation between IL-18 level and CVD were summarized. Compared with patients with CVD, the mean of IL-18 level in the normal group was significantly decreased by 50.844 pg/ml (P 0.05), and the association between IL-18-607C/A and IL-18 level was also not significant (P > 0.05), Mendelian randomization study was failed to prove the association between IL-18 level and CVD risk. Conclusion This study does not support a causal association between IL-18 level and the risks of CVD. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1601-5223 |
| Relation: |
http://link.springer.com/article/10.1186/s41065-020-00121-5; https://doaj.org/toc/1601-5223 |
| DOI: |
10.1186/s41065-020-00121-5 |
| Access URL: |
https://doaj.org/article/834ebd2fb09e4973a9971213ca95173f |
| Accession Number: |
edsdoj.834ebd2fb09e4973a9971213ca95173f |
| Database: |
Directory of Open Access Journals |
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