Sleep alterations as a predictor of bipolar disorder among offspring of parents with bipolar disorder: a systematic review and meta-analysis
| Title: | Sleep alterations as a predictor of bipolar disorder among offspring of parents with bipolar disorder: a systematic review and meta-analysis |
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| Authors: | Kyara Rodrigues de Aguiar, Mariana Dias Cabelleira, Bruno Braga Montezano, Karen Jansen, Taiane de Azevedo Cardoso |
| Source: | Trends in Psychiatry and Psychotherapy, Vol 43, Iss 4, Pp 256-269 (2021) |
| Publisher Information: | Associação de Psiquiatria do Rio Grande do Sul, 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Psychiatry |
| Subject Terms: | Bipolar disorder, high-risk offspring, sleep disorder, Psychiatry, RC435-571 |
| More Details: | Abstract Introduction Bipolar disorder (BD) has a high heritability rate. Current studies have been dedicated to identifying prodromes of BD in the offspring of parents with BD (BO) and the sleep patterns of these individuals have been considered important factors. Objective To describe changes in sleep parameters among offspring of parents with BD when compared to offspring of controls and to identify if changes in parameters and quality of sleep predict the onset of BD among these individuals. Methods PubMed, PsycINFO, and Embase were systematically searched with no year or language restrictions, up to August 18, 2020. We searched for a combination of the following search items (“sleep*”) AND (“bipolar disorder*” OR “mania” OR “hypomania” OR “bipolar depression”) AND (“ultra-high risk” OR “high risk” OR “offspring” OR “first degree relatives”). Results A total of 10 studies were included in the systematic review and 4 studies were included in the meta-analysis. Our meta-analysis showed that the BO had greater daytime sleepiness as compared to the offspring of control parents. The systematic review indicated that shorter sleep duration, sleep disorders, and other related features can differentiate the two groups. Finally, some sleep patterns such as decreased sleep, difficulty falling asleep, and overall sleep problems might be predictors for the development of BD. Conclusion Results from the meta-analysis indicated that BO had greater daytime sleepiness. Qualitative results showed that the offspring of parents with BD have an increased likelihood of experiencing an adverse sleep pattern. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English Spanish; Castilian Portuguese |
| ISSN: | 2238-0019 2237-6089 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2237-60892021000400256&tlng=en; https://doaj.org/toc/2238-0019 |
| DOI: | 10.47626/2237-6089-2021-0256 |
| Access URL: | https://doaj.org/article/8321dca87ab741f7ad88264439b10cfa |
| Accession Number: | edsdoj.8321dca87ab741f7ad88264439b10cfa |
| Database: | Directory of Open Access Journals |
| ISSN: | 22380019 22376089 |
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| DOI: | 10.47626/2237-6089-2021-0256 |
| Published in: | Trends in Psychiatry and Psychotherapy |
| Language: | English Spanish; Castilian Portuguese |