Bibliographic Details
| Title: |
Combined sedation in pediatric magnetic resonance imaging: determination of median effective dose of intranasal dexmedetomidine combined with oral midazolam |
| Authors: |
Hao Xie, Jialian Zhao, Haiya Tu, Wenyang Wang, Yaoqin Hu |
| Source: |
BMC Anesthesiology, Vol 24, Iss 1, Pp 1-9 (2024) |
| Publisher Information: |
BMC, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Anesthesiology |
| Subject Terms: |
Combined sedation, Intranasal dexmedetomidine, Oral midazolam, Pediatric magnetic resonance imaging, Median effective dose, Anesthesiology, RD78.3-87.3 |
| More Details: |
Abstract Background The exact median effective dose (ED50) of intranasal dexmedetomidine combined with oral midazolam sedation for magnetic resonance imaging (MRI) examination in children remains unknow and the aim of this study was to determine the ED50 of their combination. Methods This is a prospective dose-finding study. A total of 53 children aged from 2 months to 6 years scheduled for MRI examination from February 2023 to April 2023 were randomly divided into group D (to determine the ED50 of intranasal dexmedetomidine) and group M (to determine the ED50 of oral midazolam). The dosage of dexmedetomidine and midazolam was adjusted according to the modified Dixon’s up-and-down method, and the ED50 was calculated with a probit regression approach. Results The ED50 of intranasal dexmedetomidine when combined with 0.5 mg∙kg− 1 oral midazolam was 0.39 µg∙kg− 1 [95% confidence interval (CI) 0.30 to 0.46 µg∙kg− 1] while the ED50 of oral midazolam was 0.17 mg∙kg− 1 (95% CI 0.01 to 0.29 mg∙kg− 1) when combined with 1 µg∙kg− 1 intranasal dexmedetomidine. The sedation onset time of children with successful sedation in group D was longer than in group M (30.0[25.0, 38.0]vs 19.5[15.0, 35.0] min, P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1471-2253 |
| Relation: |
https://doaj.org/toc/1471-2253 |
| DOI: |
10.1186/s12871-024-02493-x |
| Access URL: |
https://doaj.org/article/82dcf88d885a41e6bcde41830f5dbcd3 |
| Accession Number: |
edsdoj.82dcf88d885a41e6bcde41830f5dbcd3 |
| Database: |
Directory of Open Access Journals |
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