AgNOR patterns and configurations in adult acute leukemia patients
| Title: | AgNOR patterns and configurations in adult acute leukemia patients |
|---|---|
| Authors: | Małgorzata Gajewska, Iwona Kwiecień, Elżbieta Rutkowska, Piotr Rzepecki, Kazimierz Sułek |
| Source: | Central European Journal of Immunology, Vol 47, Iss 4, Pp 323-331 (2023) |
| Publisher Information: | Termedia Publishing House, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Medicine |
| Subject Terms: | bone marrow, acute leukemia, argyrophilic nucleolar organizer regions, blasts, ag-nor patterns, Medicine |
| More Details: | The number of argyrophilic nucleolus organizer regions (AgNOR) is related to the proliferative activity of cells and the degree of neoplastic transformation. The surface area of AgNOR depending on nuclear structure may be a predictor of tumor recurrence, while research into acute leukemias is scarce. The aim of the study was to determine whether the assessment of AgNOR parameters is useful in the differentiation of acute leukemias and, together with cytogenetic changes, would allow for a quick evaluation of the risk group. The AgNOR structures were analyzed in terms of the shape, surface area and distribution in bone marrow blast cells in patients with acute leukemias. We observed significant differences in the AgNOR structures, simple, compound and complex patterns between acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Complex structures were more numerous in ALL than in AML patients. There were significant differences in the distribution of AgNOR configuration among various cytogenetic AML risk groups. We observed a significant difference in the mean number of AgNOR between ALL-T and ALL-B. We detected diversity in the AgNOR structures and pattern map in AML and ALL. Thus, presentation of a variety of AgNOR configurations is innovative and can be a useful method of differentiating patients with acute leukemia types and cytogenetic risk. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1426-3912 1644-4124 |
| Relation: | https://www.termedia.pl/AgNOR-patterns-and-configurations-in-adult-acute-leukemia-patients,10,49966,1,1.html; https://doaj.org/toc/1426-3912; https://doaj.org/toc/1644-4124 |
| DOI: | 10.5114/ceji.2022.124252 |
| Access URL: | https://doaj.org/article/82d0ecd83c7440f3b124e9a4235a7136 |
| Accession Number: | edsdoj.82d0ecd83c7440f3b124e9a4235a7136 |
| Database: | Directory of Open Access Journals |
| ISSN: | 14263912 16444124 |
|---|---|
| DOI: | 10.5114/ceji.2022.124252 |
| Published in: | Central European Journal of Immunology |
| Language: | English |