| Title: |
Predictive value of bowel dose-volume for severe radiation-induced lymphopenia and survival in cervical cancer |
| Authors: |
Jingjing Li, Qingqing Chen, Zhengcao Liu, Yingying Xu, Shengjun Ji |
| Source: |
Frontiers in Immunology, Vol 15 (2024) |
| Publisher Information: |
Frontiers Media S.A., 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Immunologic diseases. Allergy |
| Subject Terms: |
cervical cancer, radiation-induced lymphopenia, bowel, dose-volume, prognosis, Immunologic diseases. Allergy, RC581-607 |
| More Details: |
BackgroundRadiation-induced lymphopenia (RIL) is closely related to the prognosis of cervical cancer patients and may affect the efficacy of immune checkpoint inhibitors (ICIs). However, the factors influencing RIL are not very clear. In addition to bone marrow (BM) dose-volume, animal studies indicate radiation-induced bowel injury may be a more crucial factor. Further clarification of the correlation between RIL and bowel dose-volume is important for cervical cancer treatment.MethodsCervical cancer patients treated with postoperative radiotherapy or radical radiotherapy were eligible for this retrospective study. Clinical characteristics, dose parameters of bowel and BM, planning target volume (PTV) size, overall survival (OS) and progression-free survival (PFS) were recorded. The absolute lymphocyte count |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-3224 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fimmu.2024.1459206/full; https://doaj.org/toc/1664-3224 |
| DOI: |
10.3389/fimmu.2024.1459206 |
| Access URL: |
https://doaj.org/article/82d077dcae434f0ba78536c4be38673f |
| Accession Number: |
edsdoj.82d077dcae434f0ba78536c4be38673f |
| Database: |
Directory of Open Access Journals |
