Academic Journal
Risk factors for long-term survival in patients with ypN+ M0 rectal cancer after radical anterior resection
| Title: | Risk factors for long-term survival in patients with ypN+ M0 rectal cancer after radical anterior resection |
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| Authors: | Marcin Zeman, Władysław Skałba, Piotr Szymański, Grzegorz Hadasik, Dmytro Żaworonkow, Dominik A. Walczak, Agnieszka Czarniecka |
| Source: | BMC Gastroenterology, Vol 22, Iss 1, Pp 1-11 (2022) |
| Publisher Information: | BMC, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Diseases of the digestive system. Gastroenterology |
| Subject Terms: | Angiotensin-converting enzyme inhibitors, Lymph node metastasis, Lymph node yield, Negative lymph node count, Rectal cancer, Renin-angiotensin system, Diseases of the digestive system. Gastroenterology, RC799-869 |
| More Details: | Abstract Background Regional lymph node metastases are the main adverse prognostic factor in patients with rectal cancer without distant metastases. There are discrepancies, however, regarding additional risk factors in the group of ypN + M0 patients. The purpose of the study was to assess clinical and pathological factors affecting long-term oncological outcomes in the group of ypN + M0 patients after radical rectal anterior resection. Methods 112 patients with ypN + M0 rectal cancer after neoadjuvant therapy and radical anterior resection were subject to a retrospective analysis. The effect of potential factors on survival was assessed with the use of Kaplan–Meier curves together with a log-rank test and multiple factor Cox proportional hazards model. Results In the multiple factor Cox analysis, adverse factors affecting disease-free survival (DFS) were: the use of angiotensin-converting enzyme inhibitors (ACEIs) (hazard ratio HR: 3.11, 95% CI 1.01–9.56, p = 0.047), presence of perineural invasion (HR: 7.27, 95% CI 2.74–19.3, p 7 (HR: 0.33, 95% CI 0.12–0.88, p = 0.026). In the disease-specific survival (DSS) analysis, an adverse factor was the use of ACEIs (HR: 4.275, 95% CI 1.44–12.694, p = 0.009), while a positive effect was caused by NLN > 5 (HR: 0.22, 95% CI 0.082–0.586, p = 0.002). Conclusions The use of ACEIs may have a negative effect on long-term treatment outcomes in patients with ypN + M0 rectal cancer. In this group of patients, the NLN count seems to be an important prognostic factor, as well. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1471-230X 93834675 |
| Relation: | https://doaj.org/toc/1471-230X |
| DOI: | 10.1186/s12876-022-02226-9 |
| Access URL: | https://doaj.org/article/82c138a9a1ad47ab93834675115ed2de |
| Accession Number: | edsdoj.82c138a9a1ad47ab93834675115ed2de |
| Database: | Directory of Open Access Journals |
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| ISSN: | 1471230X 93834675 |
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| DOI: | 10.1186/s12876-022-02226-9 |
| Published in: | BMC Gastroenterology |
| Language: | English |