| Title: |
Mitochondrial apoptosis and BH3 mimetics [version 1; referees: 3 approved] |
| Authors: |
Haiming Dai, X. Wei Meng, Scott H. Kaufmann |
| Source: |
F1000Research, Vol 5 (2016) |
| Publisher Information: |
F1000 Research Ltd, 2016. |
| Publication Year: |
2016 |
| Collection: |
LCC:Medicine
LCC:Science |
| Subject Terms: |
Cancer Therapeutics, Cell Signaling, Cellular Death & Stress Responses, Immunopharmacology & Hematologic Pharmacology, Leukemia & Proliferative Disorders of Hematic Cells, Membranes & Sorting, Pediatric Hematology, Pediatric Oncology, Medicine, Science |
| More Details: |
The BCL2-selective BH3 mimetic venetoclax was recently approved for the treatment of relapsed, chromosome 17p-deleted chronic lymphocytic leukemia (CLL) and is undergoing extensive testing, alone and in combination, in lymphomas, acute leukemias, and solid tumors. Here we summarize recent advances in understanding of the biology of BCL2 family members that shed light on the action of BH3 mimetics, review preclinical and clinical studies leading to the regulatory approval of venetoclax, and discuss future investigation of this new class of antineoplastic agent. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2046-1402 |
| Relation: |
https://f1000research.com/articles/5-2804/v1; https://doaj.org/toc/2046-1402 |
| DOI: |
10.12688/f1000research.9629.1 |
| Access URL: |
https://doaj.org/article/82afa4c14b1641aba5f3ca3068b3ba7b |
| Accession Number: |
edsdoj.82afa4c14b1641aba5f3ca3068b3ba7b |
| Database: |
Directory of Open Access Journals |
