Bibliographic Details
| Title: |
Non-neutralizing anti-type I interferon autoantibodies could increase thrombotic risk in critical COVID-19 patients |
| Authors: |
Mario Framil, Lydia García-Serrano, Francisco Morandeira, Juan Francisco Luchoro, Arnau Antolí, Jose Luis Gomez-Vazquez, Àngels Sierra-Fortuny, Xavier Solanich |
| Source: |
Frontiers in Immunology, Vol 16 (2025) |
| Publisher Information: |
Frontiers Media S.A., 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Immunologic diseases. Allergy |
| Subject Terms: |
non-neutralizing autoantibodies, type I interferon, COVID-19, thrombotic complications, endothelial dysfunction, ICU patients, Immunologic diseases. Allergy, RC581-607 |
| More Details: |
During the COVID-19 pandemic, approximately 15% of patients with severe COVID-19 pneumonia were reported to have neutralizing anti-type I interferon (IFN) autoantibodies, which impaired the antiviral response and led to a poorer prognosis. However, the physiological impact of non-neutralizing autoantibodies remains unclear. In our cohort of COVID-19 patients admitted to intensive care, the presence of non-neutralizing anti-type I IFN autoantibodies increased the risk of thrombotic complications, likely via a cytokine carrier mechanism, prolonging the half-life of cytokines and dysregulating vascular endothelial function. Previous studies have associated non-neutralizing anti-type I IFN autoantibodies with an increased risk of cardiovascular complications in autoimmune diseases like systemic lupus erythematosus, but their relevance in infectious diseases remains uncertain. Stratifying anti-type I IFN autoantibodies based on their neutralizing capacity may have clinical significance not only in terms of susceptibility to infectious diseases but also in predicting cardiovascular and thrombotic events. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-3224 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fimmu.2025.1556731/full; https://doaj.org/toc/1664-3224 |
| DOI: |
10.3389/fimmu.2025.1556731 |
| Access URL: |
https://doaj.org/article/e829327374e8487e994b862b1bfdf17a |
| Accession Number: |
edsdoj.829327374e8487e994b862b1bfdf17a |
| Database: |
Directory of Open Access Journals |
