Academic Journal
Polydopamine-Coated Poly-Lactic Acid Aerogels as Scaffolds for Tissue Engineering Applications
| Title: | Polydopamine-Coated Poly-Lactic Acid Aerogels as Scaffolds for Tissue Engineering Applications |
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| Authors: | Ramona Orlacchio, Simona Zuppolini, Iriczalli Cruz-Maya, Stefania Pragliola, Anna Borriello, Vincenzo Guarino, Rosalba Fittipaldi, Mariateresa Lettieri, Vincenzo Venditto |
| Source: | Molecules, Vol 27, Iss 7, p 2137 (2022) |
| Publisher Information: | MDPI AG, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Organic chemistry |
| Subject Terms: | poly-lactic acid, polydopamine, aerogels, scaffolds, Organic chemistry, QD241-441 |
| More Details: | Poly-L-lactic acid (PLLA) aerogel-based scaffolds were obtained from physical PLLA gels containing cyclopentanone (CPO) or methyl benzoate (BzOMe) molecules. An innovative single step method of solvent extraction, using supercritical CO2, was used to achieve cylindrical monolithic aerogels. The pore distribution and size, analyzed by SEM microscopy, were found to be related to the crystalline forms present in the physical nodes that hold the gels together, the stable α’-form and the metastable co-crystalline ε-form, detected in the PLLA/BzOMe and PLLA/CPO aerogels, respectively. A higher mechanical compressive strength was found for the PLLA/CPO aerogels, which exhibit a more homogenous porosity. In vitro biocompatibility tests also indicated that monolithic PLLA/CPO aerogels exhibited greater cell viability than PLLA/BzOMe aerogels. An improved biocompatibility of PLLA/CPO monolithic aerogels was finally observed by coating the surface of the aerogels with polydopamine (PDA) obtained by the in situ polymerization of dopamine (DA). The synergistic effect of biodegradable polyester (PLLA) and the biomimetic interface (PDA) makes this new 3D porous scaffold, with porosity and mechanical properties that are tunable based on the solvent used in the preparation process, attractive for tissue engineering applications. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1420-3049 82608229 |
| Relation: | https://www.mdpi.com/1420-3049/27/7/2137; https://doaj.org/toc/1420-3049 |
| DOI: | 10.3390/molecules27072137 |
| Access URL: | https://doaj.org/article/82608229a4414ce7b62751073d27920c |
| Accession Number: | edsdoj.82608229a4414ce7b62751073d27920c |
| Database: | Directory of Open Access Journals |
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| ISSN: | 14203049 82608229 |
|---|---|
| DOI: | 10.3390/molecules27072137 |
| Published in: | Molecules |
| Language: | English |