Bibliographic Details
| Title: |
Detection of HPV RNA molecules in stratified mucin-producing intraepithelial lesion (SMILE) with concurrent cervical intraepithelial lesion: a case report |
| Authors: |
Shiho Fukui, Kazunori Nagasaka, Naoko Iimura, Ranka Kanda, Takayuki Ichinose, Takeru Sugihara, Haruko Hiraike, Shunsuke Nakagawa, Yuko Sasajima, Takuya Ayabe |
| Source: |
Virology Journal, Vol 16, Iss 1, Pp 1-5 (2019) |
| Publisher Information: |
BMC, 2019. |
| Publication Year: |
2019 |
| Collection: |
LCC:Infectious and parasitic diseases |
| Subject Terms: |
Stratified mucin-producing intraepithelial lesion, Cervical intraepithelial lesion, Cancer stem cell, Human papillomavirus, Infectious and parasitic diseases, RC109-216 |
| More Details: |
Abstract Background Stratified mucin-producing intraepithelial lesion (SMILE) is a rare precursor lesion in the uterine cervix that is considered a variant of adenocarcinoma in situ (AIS). Although human papillomavirus (HPV) is thought to be related to the development of SMILE, there is little information available on the detection of HPV integrated into the lesion. Case presentation A 30-year-old female underwent a routine uterine cervical cancer screening, and her Pap smear indicated the possible existence of atypical glandular cells. A cervical biopsy with endocervical curettage was performed. The histopathological analysis showed that she had SMILE and high-grade squamous intraepithelial lesion (HSIL) on her cervix. The lesion was found to be positive for HPV genotypes 52 and 68 by multiplex PCR. In situ hybridization with HPV RNA probes revealed that these HPV types were involved in the onset of HSIL and SMILE, respectively. Conclusions Rare, high-risk HPV genotypes may contribute to the development of SMILE, and their detection can be useful for preventing the progression to carcinoma and ensuring adequate patient management. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1743-422X |
| Relation: |
http://link.springer.com/article/10.1186/s12985-019-1180-2; https://doaj.org/toc/1743-422X |
| DOI: |
10.1186/s12985-019-1180-2 |
| Access URL: |
https://doaj.org/article/823c273b841f419ba05f9c40ed6cabda |
| Accession Number: |
edsdoj.823c273b841f419ba05f9c40ed6cabda |
| Database: |
Directory of Open Access Journals |
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