Bibliographic Details
| Title: |
From Translation to Protein Degradation as Mechanisms for Regulating Biological Functions: A Review on the SLRP Family in Skeletal Tissues |
| Authors: |
Jérémie Zappia, Marc Joiret, Christelle Sanchez, Cécile Lambert, Liesbet Geris, Marc Muller, Yves Henrotin |
| Source: |
Biomolecules, Vol 10, Iss 1, p 80 (2020) |
| Publisher Information: |
MDPI AG, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Microbiology |
| Subject Terms: |
small leucine-rich proteoglycans, codon usage, post-translational event, glycosaminoglycan, glycosylation, catabolism, Microbiology, QR1-502 |
| More Details: |
The extracellular matrix can trigger cellular responses through its composition and structure. Major extracellular matrix components are the proteoglycans, which are composed of a core protein associated with glycosaminoglycans, among which the small leucine-rich proteoglycans (SLRPs) are the largest family. This review highlights how the codon usage pattern can be used to modulate cellular response and discusses the biological impact of post-translational events on SLRPs, including the substitution of glycosaminoglycan moieties, glycosylation, and degradation. These modifications are listed, and their impacts on the biological activities and structural properties of SLRPs are described. We narrowed the topic to skeletal tissues undergoing dynamic remodeling. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2218-273X |
| Relation: |
https://www.mdpi.com/2218-273X/10/1/80; https://doaj.org/toc/2218-273X |
| DOI: |
10.3390/biom10010080 |
| Access URL: |
https://doaj.org/article/81e2a973072041759626278792ecf30e |
| Accession Number: |
edsdoj.81e2a973072041759626278792ecf30e |
| Database: |
Directory of Open Access Journals |
